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Skip to Search Results- 1Abdul Rahman, Siti Aishah
- 1Alles, Sascha R
- 1Chadwick, Caylin Isabelle
- 1Chen, Yishen
- 1Dimopoulos, Ioannis
- 1Dorfman, Tamara L.
- 5Centre for Neuroscience
- 5Department of Pharmacology
- 4Neuroscience
- 3Department of Physiology
- 3Faculty of Nursing
- 1Department of Agricultural, Food and Nutritional Science
- 2Tse, Amy (Centre for Neuroscience and Department of Pharmacology)
- 1Baksh, Shairaz (Pediatrics)
- 1Ballanyi, Klaus (Physiology Department, University of Alberta)
- 1Chen, Xing-Zhen (Physiology)
- 1Clayton T. Dickson (Psychology, Physiology, Anesthesia and Pain Medicine, Neuroscience and Mental Health Institute)
- 1Colmers, William F. (Pharmacology)
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Instruments for Scoring Pain, Non-Pain Related Distress, Analgesia, and Sedation in Pediatric Mechanically Ventilated Patients and their Efficacy and Effectiveness in Practice: A Systematic Review
DownloadFall 2012
Objective pain and sedation assessment scales to standardize measures of distress in mechanically ventilated pediatric patients are increasingly available, but few have been evaluated for efficacy and effectiveness in this population. The purpose of paper one was to identify and evaluate...
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Fall 2009
The computational ability of principal neurons and interneurons in the brain and their ability to work together in concert are thought to underlie higher order cognitive processes such as learning, memory, and attention. Dendrites play a very important role in neuronal information processing...
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Molecular and Epigenetic Insights into RASSF1A Regulated Pathways in Inflammatory Bowel Disease
DownloadFall 2018
Inflammatory Bowel Disease (IBD) is an idiopathic non-curable disease characterized by pain, chronic diarrhea, rectal bleeding with weight loss and erosion of the colon in severe cases. In many cases, IBD is a chronic relapsing inflammatory disorder of the gastrointestinal tract that usually...
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Fall 2015
Youssef, Nermeen Hosny Ibrahim
Plasma membrane ATP-sensitive potassium (KATP) channels are found in many excitable cell types where they couple cellular metabolism and membrane excitability. . Studies on KATP deficient mice show that parameters of cardiac mechanical function are similar to those of wild-type mice under basal...
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Pain and analgesia in experimental autoimmune encephalomyelitis: Contribution of the central nucleus of the amygdala
DownloadSpring 2021
Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation, degeneration and demyelinating lesions within the central nervous system. Chronic pain is a highly prevalent symptom associated with MS, affecting 50-80% of patients over the course of their disease....
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Pharmacological and Fluorometric Assessment of Neuronal KCNQ Channels, and Implications for Understanding Neurological Disease
DownloadSpring 2020
Epilepsy affects 60 million people worldwide, and encompasses the most common forms of neurological disorders. Epilepsy manifests in diverse ways in patients, ranging from mild cognitive effects, to seizures, to the more severe epileptic encephalopathy. While many pharmacological approaches exist...
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Fall 2013
Glomus cells of the carotid body are peripheral chemoreceptors that detect changes in arterial oxygen levels. Hypoxia suppresses oxygen-sensitive K+ channels in glomus cells, resulting in cytosolic Ca2+ ([Ca2+]i) elevation in glomus cells via the activation of voltage-gated Ca2+ channels. The...
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Regulation of Cardiac Gap Junctional Communication: Metabolic regulation of Cx40 and Cx43 via phosphorylation
DownloadFall 2015
Alterations in myocardial metabolism and cardiac electrophysiology associated with structural heart disease generate lethal arrhythmias. Differential levels of energy (ATP) supply and demand are generated with structural heart disease that is expected to activate 5’-amp activated protein kinase...