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- 2Activation-induced cytidine deaminase
- 2Class switch recombination
- 2Somatic hypermutation
- 1Affinity maturation
- 1Aicda
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Fall 2022
Affinity maturation is the process to improve antibody affinity for an antigen during an adaptive immune response; it is mediated by the immunoglobulin mutator enzyme activation-induced cytidine deaminase (AID). This process is crucial to produce high-affinity memory B-cells and plasma cells. In...
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Fall 2020
Antigen-specific recognition and memory, the hallmarks of conventional mammalian adaptive immunity, are found in all jawed vertebrates along with all elements central to cognate adaptive immune responses (e.g. B-cells). During T-cell-dependent humoral immune responses in mammals, antigen-specific...
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Transcriptional regulation of the zebrafish activation-induced cytidine deaminase (AID) gene
DownloadFall 2012
Activation-induced cytidine deaminase (AID, encoded by Aicda) mediates affinity maturation of immunoglobulin genes. Early studies in mammals indicated that the transcription of Aicda was regulated by a number of transcriptional regulatory regions, including a B-cell specific enhancer in the...