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Bridging COVID-19-mediated Myocardial Inflammation and the Epicardial Adipose Tissue in Heart Failure: ACE2 Regulation at Center Stage
DownloadFall 2023
ACE2 was discovered as the primary effector enzyme of the protective, counter-regulatory arm of the renin-angiotensin system (RAS). The canonical RAS, comprising the angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/AT 1 receptor (AT1R) axis, mediates proinflammatory, profibrotic, and...
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Fall 2021
Hypertension is the leading cause of global morbidity and mortality, afflicting > 20% of adults worldwide (~1 in 4 in Canada). Pharmaceutical drugs are the primary treatment for hypertension, but are generally associated with side effects. Recently, food-derived antihypertensive peptides are...
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The Regulatory Roles of Peptide IRW on angiotensin-converting enzyme 2 (ACE2) in High-Fat Diet-Induced Mice and Spontaneously Hypertensive Rats
DownloadFall 2023
Metabolic syndrome (MetS) refers to a cluster of various risk factors commonly associated with cardiovascular diseases (CVDs) and diabetes. Up-regulation of angiotensin-converting enzyme 2 (ACE2), a key member of the renin-angiotensin system (RAS), is generally protective against CVDs and...
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Spring 2016
Both ACE2 and apelin have been reported playing important roles in regulating cardiovascular structure and function. In this study, we used ACE2 or apelin gene knockout or knockdown mice to explore the roles of ACE2 or apelin in cardiovascular diseases. In particular, we created animal disease...