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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Akinwumi, Segun M
- 1Alanis, Ramon
- 1Bhavanam,Sudha
- 1Boulet, Joel L
- 1Chakraborty, Tathagata
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A novel mouse model of acute antibody-mediated transplant rejection shows simultaneous complement activating and anti-inflammatory effects of donor specific IgG antibodies
DownloadFall 2013
We developed a small animal model of pure antibody-mediated rejection (ABMR) by utilizing fully major histocompatibility complex (MHC) mismatched kidney allografts in mice. By examining resultant ABMR pathology, we show that terminal complement products C5a and C5b-9 are crucial in establishing...
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Fall 2020
Introduction: ABO-incompatible organ transplants (ABOi-Tx) recipients are at high-risk of rapid rejection mediated by ABO antibodies (ABO Abs). To manage and expand ABOi-Tx, it is necessary to understand the mechanism(s) by which natural and induced ABO Abs develop. Prior studies have used...
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Fall 2014
Carbohydrate–protein interactions play key roles in a range of biological processes. Noticeable advancements have been made in understanding the features associated with the recognition of pyranosides (six-membered ring sugars) by proteins. In contrast, similar detailed studies about the...
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Behind the Mask: A Narrative Inquiry into Operating Room Nurses' Experiences of Patient Safety
DownloadSpring 2013
The delivery of safe care is an expectation and a central concern of individuals using the healthcare system, particularly for those who find themselves as patients in hospitals. Healthcare researchers' reports and discussions of harm while receiving hospital services speak to the global...
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Characterization of Binding of LILRA3 and LILRB2 to the Myelin-Associated Inhibitors and Major Histocompatibility Class I Molecules
DownloadFall 2018
The leukocyte immunoglobulin-like receptor family (LILR) is composed of inhibitory and activating receptors that are widely expressed on immune cells and interact with classical and non-classical MHC-I. Recently, several ligands have been identified for the LILRs including the three...
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Spring 2012
The purpose of this study was to explore Chinese immigrants’ experiences with human services during the transition to parenthood. The data were generated through three rounds of individual interviews with six Chinese immigrant couples. Latent content analysis was used to identify primary patterns...
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Spring 2013
The adaptive immune response against intracellular pathogens is largely mediated by CD8+ T lymphocytes. The clonal expansion and expression of cytolytic and immune stimulatory proteins by CD8+ T cells is responsible for their protective immune function. Prior to exhibiting effector activity,...
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Community Health Centres: Board Governanace and Stakeholder Relations During Service Expansion
DownloadSpring 2013
Despite a significant amount of literature on primary health care, little is understood about primary health care expansion. The current study examines community health centre (CHC) board governance during a period of expansion. Participants (board members) were identified through the publically...
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Creation of an in-vitro¬ Co-culture Model of Microglia and Retinal Pigment Epithelium Cells for Investigating the Innate Immune Mechanisms of the Retina
DownloadFall 2022
Background: The immune mechanisms of the retina in response to gene therapy have been previously understudied due to assumptions of ocular immune privilege. Ocular immune privilege is the concept that there is a tolerance or reduced immune response to antigen exposure in the eye. With the recent...
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Culture and the healthy immigrant effect: a multiethnic study of Canadian immigrants' self-perceived health
DownloadSpring 2011
I present a qualitative study investigating the self-perceived health of recently arrived Canadian immigrants. The study develops health promotion’s understanding of culture as a social determinant of health, and conceptually locates it within a broader context of psychosocial factors. The study...