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Mechanistic Basis for Enhanced Oncolytic Potency by Mutations in Reovirus Sigma1 and Mu2 proteins
DownloadSpring 2020
Wild-type mammalian orthoreoviruses (reoviruses) are non-pathogenic viruses infecting hosts via the respiratory and enteric tracts. There are four prototype reovirus strains: the Type 1 Lang (T1L), Type 2 Jones (T2J), Type 3 Abney (T3A), Type 3 Daring (T3D) and Type 4 Ndelle (T4N). A...
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