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Fall 2019
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) peptide. It has been proposed that AD pathology is transmissible by a “prion-like” mechanism through extracellular vesicles (EVs) that contain Aβ. In this context, EVs describe both microvesicles and exosomes,...
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Bridging COVID-19-mediated Myocardial Inflammation and the Epicardial Adipose Tissue in Heart Failure: ACE2 Regulation at Center Stage
DownloadFall 2023
ACE2 was discovered as the primary effector enzyme of the protective, counter-regulatory arm of the renin-angiotensin system (RAS). The canonical RAS, comprising the angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/AT 1 receptor (AT1R) axis, mediates proinflammatory, profibrotic, and...