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Investigation of the biosynthesis of lovastatin and cytochalasin E, two fungal polyketides assembled by iterative PKS-NRPS enzymes
DownloadFall 2015
Cytochalasin E and lovastatin are two fungal polyketides that have seen extensive use as an angiogenesis inhibitor and as a cholesterol-lowering agent, respectively. These structurally divergent compounds are synthesized by polymerization of acetate units with concomitant functionalization by two...
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