This decommissioned ERA site remains active temporarily to support our final migration steps to https://ualberta.scholaris.ca, ERA's new home. All new collections and items, including Spring 2025 theses, are at that site. For assistance, please contact erahelp@ualberta.ca.
Search
Skip to Search Results- 2Roczkowsky, Andrej
- 1Chan, Brandon Y.H.
- 1Davies, Peter L.
- 1Hwang, Peter M.
- 1Li, Liang
- 1Liu, Philip B.
- 1Calpain
- 1Intrinsically disordered protein
- 1Ischemia-reperfusion injury
- 1JPH-2
- 1MMP-2
- 1Mass spectrometry
-
Role of matrix metalloproteinase-2 in sarcoplasmic reticulum dysfunction during myocardial ischemia-reperfusion injury
DownloadSpring 2019
Matrix metalloproteinase-2 (MMP-2) is an intra- and extra-cellular protease which is activated during myocardial ischemia-reperfusion (IR) injury by reactive oxygen and nitrogen species, namely peroxynitrite. Upon its activation, MMP-2 impairs cardiac contractility by cleaving sarcomeric and...
-
Structure and proteolytic susceptibility of the inhibitory C-terminal tail of cardiac troponin I
Download2019-01-01
Mahmud, Zabed, Zahran, Somaya, Liu, Philip B., Reiz, Bela, Chan, Brandon Y.H., Roczkowsky, Andrej, McCartney, Christian-Scott E., Davies, Peter L., Li, Liang, Schulz, Richard, Hwang, Peter M.
Background Cardiac troponin I (cTnI) has two flexible tails that control the cardiac cycle. The C-terminal tail, cTnI135-209, binds actin to shut off cardiac muscle contraction, whereas the competing calcium-dependent binding of the switch region, cTnI146-158, by cardiac troponin C (cTnC)...