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Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22
2013
Pfrengle, F., Kawasaki, N., Paulson, J. C. , Macauley, M. S.
Differentiation of self from nonself is indispensable for maintaining B cell tolerance in peripheral tissues. CD22 and Siglec-G (sialic acid-binding Ig-like lectin G) are two inhibitory coreceptors of the BCR that are implicated in maintenance of tolerance to self Ags. Enforced ligation of CD22...
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Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells
2014
Paulson, J. C. , Macauley, M. S.
Infusion of blood cells from a donor can induce humoral tolerance in a recipient and increase the probability of successful organ transplant, a clinical method defined as donor-specific transfusion (DST). Despite the clinical success of DST, the immunological mechanisms by which blood cells...