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Skip to Search Results- 2Kassiri, Zamaneh
- 2Schulz, Richard
- 1Anderson, Todd J.
- 1Becher, Harald
- 1Belenkie, Israel
- 1Clark, Alexander M.
- 1Apoptosis
- 1Embryonic Lethality
- 1Fas
- 1Heart failure
- 1Heart failure diagnosis
- 1Heart failure risk factors
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Multicentric osteolysis with nodulosis, arthritis, and cardiac defect syndrome: loss of MMP2 leads to increased apoptosis with alteration of apoptotic regulators and caspases and embryonic lethality
Download2014-01-01
Martignetti, John A., Mosig, Rebecca A., Schulz, Richard, Kassiri, Zamaneh, Schaffler, Mitchell B.
Inactivating mutations of matrix metalloproteinase 2 (MMP2) cause multicentric osteolysis with nodulosis and arthritis, one of a group of inherited osteolytic and arthritic disorders. We have previously shown that mice lacking Mmp2 share similar syndromic features with the human disorder, and at...
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2014-11-05
Thompson, Richard B., Oudit, Gavin Y., Paterson, D. Ian, Becher, Harald, Kaul, Padma, Knudtson, Merril L., Dyck, Jason R.B., Lopaschuk, Gary D., Belenkie, Israel, Clark, Alexander M., Schulz, Richard, Howlett, Jonathan G., Kim, Daniel H., Anderson, Todd J., Weeks, Sarah G., Haykowsky, Mark J., McAlister, Finlay A., Ezekowitz, Justin A., Friedrich, Matthias G., Quan, Hude, Duff, Henry J., Noga, Michelle L., Kassiri, Zamaneh, Light, Peter E.
Nationally, symptomatic heart failure affects 1.5-2% of Canadians, incurs $3 billion in hospital costs annually and the global burden is expected to double in the next 1–2 decades. The current one-year mortality rate after diagnosis of heart failure remains high at >25%. Consequently, new...