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Skip to Search Results- 1Chan, Catherine B.
- 1Joseph, Jamie W.
- 1Koshkin, Vasilij
- 1Lowell, Bradford B.
- 1Saleh, Monique C.
- 1Sivitz, William I.
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2004
Zhang, Chen-Yu, Chan, Catherine B., Koshkin, Vasilij, Wheeler, Michael B., Lowell, Bradford B., Joseph, Jamie W., Saleh, Monique C., Sivitz, William I.
Chronic exposure to elevated free fatty acids (lipotoxicity) induces uncoupling protein (UCP2) in the pancreatic β-cell, and therefore a causal link between UCP2 and β-cell defects associated with obesity may exist. Recently, we showed that lipid treatment in vivo and in vitro in UCP2(–/–)...