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Author / Creator / Contributor

1Elian, Fahed Ah

Item type

1Thesis

Subject / Keyword

1ErbB2-breast cancer
1Trastuzumab

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1Graduate and Postdoctoral Studies (GPS), Faculty of
1Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations

Languages

1English

Departments

1Medical Sciences-Medical Genetics

Supervisors

1Walter, Michael (Medical Genetics)
1Wang, Zhixiang (Medical Genetics)

Understanding the Mode of Action of Trastuzumab to Design a Better Therapy for ErbB2-positive Human Breast Cancer
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Spring 2016

Elian, Fahed Ah

Overexpression of ErbB2 occurs in about 25-30% of breast cancer cases and therefore, represents an attractive therapeutic target for treating breast cancer. There are two models for ErbB2 inhibitors that are currently in clinical use: humanized antibodies directed against ErbB2 and small molecule...

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Understanding the Mode of Action of Trastuzumab to Design a Better Therapy for ErbB2-positive Human Breast Cancer