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Melano-macrophage characterization and their possible role in the goldfish (Carassius auratus) antibody affinity maturation
DownloadSpring 2013
During the antibody affinity maturation process, changes to the immunoglobulin genes are initiated by the B-cell specific enzyme activation-induced cytidine deaminase (AID). These changes are randomly generated and produce antibodies with different affinities for the antigen. In mammals, this...
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