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Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic ß-cells
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Wheeler, Michael B., Chan, Catherine B., Dai, Feihan F., Koshkin, Vasilij, Robson-Doucette, Christine A.
Involvement of the mitochondrial permeability transition (MPT) pore in early stages of lipotoxic stress in the pancreatic β-cell lines MIN6 and INS-1 was the focus of this study. Both long term (indirect) and acute (direct) effects of fatty acid (FA) application on β-cell susceptibility to...
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