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Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells
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Vandorpe, D.H., Izumo, S., Malek, A.M., Goss, G.G., Jiang, L., Alper, S.L.
Background and Purpose—Hyperosmotic mannitol therapy is widely used in the clinical setting for acute and subacute reduction in brain edema, to decrease muscle damage in compartment syndrome, and to improve renal perfusion. Though beneficial rheological effects commonly are attributed to...
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