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The effect of fluconazole on cytochrome P450 1B1, formation of arachidonic acid metabolites, and protection against angiotensin II-induced cardiac hypertrophy
DownloadFall 2018
Several studies have elucidated the role of cytochrome P450s (CYPs) and their associated arachidonic acid (AA) metabolites in development of cardiac hypertrophy. CYP1B1 has been reported to have a major role in metabolizing AA into cardiotoxic metabolites, mid-chain hydroxyeicosatetraenoic acid...
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