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Skip to Search Results- 1Apoptotic Stimulating Proteins of p53
- 1Calcineurin
- 1Disruption of iASPP to PP-1cα
- 1Drug development
- 1IASPP
- 1Immunosuppressants
Results for "supervisors_tesim:"Holmes, Charles (Biochemistry)""
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The Disruption of iASPP Binding to PP-1cα via Small Molecules Sourced from Marine Organisms
DownloadFall 2017
Protein Phosphatase-1 (PP-1c) is a broad specificity Ser/Thr phosphatase catalytic subunit responsible for a variety protein dephosphorylation events in eukaryotic cells. The specificity and activity of PP-1c is largely controlled by over 200 regulatory subunits, including the Apoptotic...
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Study of calcineurin interaction with inhibitor-1 and natural products. Towards novel calcineurin inhibitors
DownloadSpring 2012
Calcineurin (CaN) is an eukaryotic Ser/Thr protein phosphatase that plays an important role in lymphocyte activation. Inhibition of CaN leads to immune system suppression, a necessary procedure in organ transplantation. However, use of CaN inhibitors results in toxic side effects. The search for...
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Fall 2017
The Apoptotic Stimulating Proteins of p53 (ASPPs) are key regulators of the human tumour suppressor transcription factor, p53. These regulators either activate (ASPP1 and ASPP2) or inhibit (iASPP) p53’s function in response to DNA damage. iASPP is overexpressed and attributed to poor survival in...