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Skip to Search Results- 2Dectin-1
- 1Beta-glucan
- 1C-type lectin Receptors (CLRs)
- 1CD36, Lipid Nanodomains, F-actin
- 1Dectin
- 1Endocytosis
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Fall 2014
Fungal pathogens are recognized by Dectin-1, a pattern recognition receptor expressed on mammalian innate immune cells. Dectin-1 detects β-glucans, which are polymers of glucose that are a main component of the fungal cell wall. While purified, soluble β-glucans have been used in the clinic as...
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Molecular Mechanisms of the Activation of the Pattern Recognition Receptor Dectin-1 and its Induction of Immune Responses
DownloadFall 2014
In the past two decades, a rising number of fungi have emerged as serious human pathogens and the incidence of invasive fungal infections has increased enormously. Millions of people contract fungal diseases that kill at least as many people as tuberculosis or malaria, yet the global burden of...
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Fall 2018
CD36, a multi-ligand plasma membrane receptor, has been implicated in immunity, metabolism and angiogenesis. We have recently demonstrated that CD36 nanoclustering at the plasma membrane is key to the initiation of CD36 signaling. In endothelial cells (ECs), the binding of thrombospondin-1...