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Fall 2012
Melanoma has the most rapidly rising incidence of all cancers and once metastasized it is very difficult to treat. This makes the identification of molecular pathways that are deregulated in melanoma a novel area of study. β-catenin (β-cat) is a multifunctional protein of the Wnt signaling...
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Spring 2016
Osteosarcoma (OS) is the most common primary bone malignancy with a high incidence in children and adolescents. Current treatment strategies (surgery and adjuvant chemotherapy) has improved the overall survival rate of patients with primary OS. However, the survival rate of patients with...
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β-catenin is O-GlcNAc modified at Serine 23: Implications for β-catenin’s Subcellular Distribution and Transcriptional Activity
DownloadFall 2012
β-catenin is a potent oncoprotein that serves as a structural anchor at the adherens junctions and as a transcriptional co-activator of the Wnt Signaling pathway. β-catenin was identified to be post-translationally modified by O-linked β-D-N-acetyl-glucosamine (O-GlcNAc). This investigation was...