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Development of a Novel Piglet Model to Simulate the Physiology of a Child with Hypoplastic Left Heart Syndrome during the First Interstage for Investigating Changes in Tricuspid Valve as it Adapts to a High-pressure and High-volume Stress Environment
DownloadSpring 2020
INTRODUCTION: Tricuspid valve (TV) failure develops in 25-35% of children with hypoplastic left heart syndrome (HLHS) and is a risk factor for morbidity and mortality. The mechanisms underlying TV failure in HLHS are not well understood. There is no effective medical therapy and current surgical...
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Spring 2020
Chronic kidney disease and end-stage renal disease (ESRD) are becoming increasingly prevalent in the world. The World Health Organization estimates that in 2015, 1.2 million people died from kidney failure, an increase of 32% from a decade ago. An estimated 2 million people worldwide are...
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Fall 2020
Ex Vivo Heart Perfusion (EVHP) preserves a donor heart’s natural beating function outside of the body. The purpose of this work was to study the influence of mock aorta properties on pump performance in a mechanical EVHP system. Previous work has shown potential benefits on pump workload by...