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Fall 2017
In Southwestern Yukon, alpine ice patches are rapidly retreating with climate warming. Ice patch forelands form unique alpine wetlands, creating critical habitats for diverse flora and fauna over millennia. A major component of the ice patch flora are bryophytes, which are critical to alpine...
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Zebrafish (Danio rerio) Leukocyte Immune-Type Receptor (DrLITR) Variable Control of the Phagocytic Response
DownloadSpring 2023
To combat microbial invaders, immune cells elicit a range of potent antimicrobial effector responses coordinated by complex intracellular signalling events. These events are initiated by the engagement of cell surface-expressed proteins, termed immunoregulatory receptors, that bind to and...
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Zebrafish embryos exposed to alcohol undergo abnormal development of motor neurons and muscle fibers
DownloadFall 2009
Children with Fetal Alcohol Spectrum Disorder have significantly delayed motor skills, and deficiencies in reflex development. The reasons underlying these motor deficits are not fully understood. The purpose of this thesis was to investigate the effect of embryonic exposure to ethanol (EtOH) on...
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Zebrafish Targeted Mutagenesis to Unveil Normal Physiological Functions of, and Interactions between, Prion Protein (PrP) and Amyloid Precursor Protein (APP): Relevance to Alzheimer’s disease
DownloadSpring 2017
Much of the work on Prion Protein (PrPC) and Amyloid Precursor Protein (APP) biology has focused on the contributions of their misfolded forms or aggregated metabolites to prion diseases and Alzheimer’s disease, respectively. As subversion/partial loss of some normal functions are also likely...