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Deciphering the mechanism(s) which limit reovirus spread in resistant lung and HNSCC cancer cells
DownloadFall 2016
Reovirus is a naturally benign virus that preferentially replicates in transformed cells and is currently undergoing clinical trials as a promising oncolytic therapy. In normal mouse fibroblasts, transformation by constitutively activated Ras oncogene is sufficient to promote reovirus infection....
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Fall 2018
Mammalian orthoreovirus (reovirus) is a non-pathogenic virus that naturally infects through the enteric and respiratory routes. Reoviruses are non-enveloped and have a 10-segment double stranded RNA (dsRNA) genome encased in 2 concentric capsid shells. Representative isolates of each of the 3...
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Mechanistic Basis for Enhanced Oncolytic Potency by Mutations in Reovirus Sigma1 and Mu2 proteins
DownloadSpring 2020
Wild-type mammalian orthoreoviruses (reoviruses) are non-pathogenic viruses infecting hosts via the respiratory and enteric tracts. There are four prototype reovirus strains: the Type 1 Lang (T1L), Type 2 Jones (T2J), Type 3 Abney (T3A), Type 3 Daring (T3D) and Type 4 Ndelle (T4N). A...