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Characterization of hypertrophic scar formation in nude and knockout mice deficient in T, B and natural killer cells
DownloadSpring 2012
Introduction: Hypertrophic scar (HSc) is a fibroproliferative disorder lacking a relevant animal model. Our objective is to characterize proliferative scars in human xenografts generated after grafting human skin onto mice deficient in T, B and natural killer cells. Methods: Nude, T-cell receptor...
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Dynamic Changes of Monocytes and Chemokine Pathway Signaling During Wound Healing Post-Burn Injury
DownloadSpring 2022
Background:There are over 11 million people hospitalized for burns annually according to the World Health Organization, resulting in painful skin scar contractures and restricted movements, as well as mental and physical stresses. Up to 70% of deep dermal injury result in hypertrophic scars,...
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Fall 2019
Background: Dermal fibroproliferative disorders are forms of aberrant cutaneous wound healing, which can lead to the formation of hypertrophic scars (HTS). HTS develop after prolonged healing of deep dermal burns and are associated with excessive inflammation. HTS are characterized by exaggerated...