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Fall 2020
Background: The CRISPR/Cas9 system has emerged as a revolutionary genetic engineering technology capable of editing various cell types, creating disease models, and more recently, changing human DNA1 . It consists of three pieces: the Cas9 endonuclease, the gRNA, and the DNA target. In short, the...
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Fall 2021
Background: Clustered Regularly Interspaced Palindromic Repeats, or CRISPR, is an array of DNA sequences found in bacteria that confer immunity against phage. Sequences within the CRISPR array are transcribed into CRISPR RNA (crRNA), which hybridize with CRISPR associated proteins (Cas) to search...
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Small-molecule inhibitors of non-structural protein 15 (NSP15) for the treatment of SARS-CoV-2
DownloadFall 2022
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic. As of 2022, the viral spread is still ongoing and has claimed the lives of at least 6.24 million globally. Despite being more than two years into the...
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Fall 2022
The ability to reliably target specific sequences of interest is a critical component of any gene editing technology. While the discovery of CRISPR-Cas systems have fundamentally simplified the way in which genomic material may be manipulated, the presence of off-target activity at undesired loci...