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Skip to Search Results- 1Abdul Rahman, Siti Aishah
- 1Acton, Leah T
- 1Aghamohammadi Sereshki, Arash
- 1Ainsley, Emily N.
- 1Bandet, Mischa V.
- 1Batty, Nicholas J.
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Sleep Disordered Breathing: Contribution of Abdominal Muscle Activation and Hormonal Intervention in Healthy and Pathological Conditions
DownloadSpring 2024
Breathing and sleep are both imperative and intricate physiological processes that require development in the perinatal period to sustain life and adapting to changes in postnatal life. Inspiration and expiration are generated by oscillatory microcircuits located in the ventrolateral medulla and...
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Fall 2023
Sleep is a vital neurobiological process, yet despite its fundamental significance, delineating the endogenous neural pathways involved has been slow to progress due to a lack of diverse sleep models. Anesthesia, which has direct behavioural parallels to natural sleep, and which is often linked...
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Structural changes of the amygdala subnuclei and limbic white matter tracts in healthy aging and major depressive disorder
DownloadFall 2019
The world population is dramatically aging. Several factors affect brain in healthy aging. The apolipoprotein E (APOE), brain-derived neurotrophic factor (BDNF) and catechol-O-methyl transferase (COMT) might be involved in neurodegenerative diseases, depression and cognitive decline in healthy...
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The Functional Role of Hippocampal Subregions and Subfields: A High-Resolution fMRI Study of Memory
DownloadFall 2017
The involvement of the hippocampus in episodic memory is well accepted. What is often overlooked is the involvement of hippocampal subfields and subregions. The hippocampal subfields Cornu Ammonis (CA), Dentate Gyrus (DG) and Subiculum (Sub) are cellularly distinct areas that communicate...
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The Role of Brain Derived Neurotrophic Factor (BDNF) and Colony Stimulating Factor (CSF-1) In the Generation of Central Sensitization and Neuropathic Pain
DownloadFall 2018
This dissertation addressed two main hypotheses: BDNF acts through different receptors and/or transduction mechanisms to increase release of excitatory transmitter onto excitatory neurons (using the Trk B signaling pathways) and to decrease release of excitatory transmitter onto inhibitory...
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The Thalamic Nucleus Reuniens Facilitates Communication Between Prefrontal Cortex and Hippocampus
DownloadSpring 2022
Decades of research have established that two brain regions, the medial prefrontal cortex (mPFC) and hippocampus (HPC), have dissociable but critical roles in memory. Often, these roles are co-operative and enable for the richness of episodic remembrances. It has remained relatively elusive,...
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The Utility of Webcam Eye-Tracking: Lessons Learned and Practical Applications in Decision-Making and Digital Human-Computer Interactions
DownloadFall 2023
In the realm of contemporary research, especially after a global pandemic, the potential of remotely-collected webcam eye-tracking has emerged as a promising yet relatively uncharted avenue. This thesis aims to both uncover and bolster the utility of this method in understanding human behaviors,...
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Thermal response of amyloidogenic elements in cultured N2a cells: potential relevance to Alzheimer’s disease pathology
DownloadFall 2020
Alzheimer’s disease (AD) weighs a large burden on health care systems, families and caregiving networks around the world. It is the most common dementia afflicting elderly individuals, and causes many debilitating symptoms, including memory loss, mood swings and confusion which progress in...
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Towards Clinical Testing of Intraspinal Microstimulation for Restoration of Walking after Spinal Cord Injury
DownloadSpring 2019
The overall goal of this thesis was to advance intraspinal microstimulation (ISMS) towards clinical testing for the purpose of restoring walking after spinal cord injury. ISMS implants focus on restoring mobility after spinal cord injury by activating the intact spinal motor networks below the...
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Spring 2018
Animal behaviour varies across hierarchical levels made up of behaviours, personality traits, and behavioural types/syndromes. Stress coping style and anxiety are examples of behavioural types, or covariance of personality traits within individuals, and can be influenced by prior stress exposure....