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Skip to Search Results- 1Abdul Rahman, Siti Aishah
- 1Acton, Leah T
- 1Aghamohammadi Sereshki, Arash
- 1Ainsley, Emily N.
- 1Bandet, Mischa V.
- 1Batty, Nicholas J.
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Fall 2023
The overarching idea of this thesis stemmed from previous work in our lab, where it was noticed that females and males exhibited different disease trajectories in a model of Multiple Sclerosis. Combined with our observation of different outcome metrics for peripheral nociception suggested that...
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Fall 2020
Patterns are predictable, ubiquitous, and functional. In something as complex and vast as the nervous system, patterns play an important role in maintaining order through logical organization. Sensory systems are one such example where neuronal organization show common patterns across modalities....
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Fall 2019
Background: Advancements in stroke imaging have allowed clinicians to more accurately select acute ischemic stroke patients for reperfusion therapies. This has moved patient selection from a time-based to an imaging-based paradigm. With few studies directly assessing the differences between...
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Peripheral contribution to pain hypersensitivity in a T-cell mediated model of multiple sclerosis: The female perspective
DownloadSpring 2020
Multiple sclerosis (MS) is a neuroinflammatory disease characterised by immune activation, demyelination, and degeneration in the central nervous system (CNS). Chronic pain is a common symptom of MS and current treatment options for pain in MS are ineffective. Pain arises from aberrant...
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Fall 2022
Peripheral nerve injuries (PNI) and peripheral nerve diseases/neuropathy (PND) are common clinical conditions characterized by varying degrees of sensory, autonomic and motor dysfunctions. Despite significant advancement in microsurgical techniques to repair the injured nerves, functional...
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Spring 2019
PINK1 (Phosphatase-Tensin homologue (PTEN)-induced putative kinase 1) is a protein kinase heavily involved in mitochondrial health and integrity. It has multiple domains: an N-terminal mitochondrial targeting sequence, a transmembrane domain, and a kinase domain. Some mutations, located...
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Reconciling organizational and cellular discrepancies between the mammalian and the avian cerebellum
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Birds and mammals have highly developed cerebella. There are many similarities at both the cellular level and the systems level between these classes, although there are some apparent differences. In this thesis, we explored two of these discrepancies. The first is a difference at the systems...
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Spring 2023
Background: Functional recovery following a spinal cord injury (SCI) is linked to neuroplasticity, including neurite outgrowth and rewiring of neuronal connections rostral and caudal to the injury. Plasticity promoting treatments can be targeted to specific locations within the central nervous...
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Fall 2018
Physical training can affect the excitability of spinal reflexes in a training-specific manner in uninjured humans. Therefore, the first part of this thesis examined the changes in the excitability of a polysynaptic and a monosynaptic reflex in an ankle plantarflexor, after contrasting forms of...
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Role of gangliosides in extracellular vesicle secretion in wild-type and Huntington's disease cell models
DownloadFall 2020
Gangliosides are sialic acid containing glycosphingolipids highly enriched in the brain that play vital roles in intercellular communication, cell signalling and calcium homeostasis. A decrease in the ganglioside levels in the brain has been associated with several neurodegenerative diseases....