This decommissioned ERA site remains active temporarily to support our final migration steps to https://ualberta.scholaris.ca, ERA's new home. All new collections and items, including Spring 2025 theses, are at that site. For assistance, please contact erahelp@ualberta.ca.
Search
Skip to Search Results- 377Faculty of Pharmacy and Pharmaceutical Sciences
- 4Faculty of Medicine
- 2Faculty of Medicine and Oral Health Sciences
- 1Department of Biomedical Engineering
- 1Department of Medical Sciences
- 1Department of Medicine
- 1AL Omair, Omar Abdulrahman
- 1AL-AGILI, MARWA
- 1Abbasi Dezfouli, Saba
- 1Abdelmoneim, AS
- 1Abdulsalam Alharbi
- 1Abdussalam, Ali MA
- 15Pharmacokinetics
- 10Cytochrome P450
- 6Cancer
- 6Monoclonal antibodies
- 6Polymeric micelles
- 5Arachidonic acid
- 8El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)
- 6El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
- 6Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 5Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 5Yuksel, Nese (Faculty of Pharmacy and Pharmaceutical Sciences)
- 4Doschak, Michael (Pharmacy and Pharmaceutical Sciences)
-
Cardioprotective Properties of a Synthetic, Structurally Mimetic 19,20- Epoxydocosapentaenoic Acid Analog: Implications of SIRT3 Potentiation on Ischemia Reperfusion Injury
DownloadFall 2024
Mounting evidence suggests that CYP epoxygenase-derived metabolites of docosahexaenoic acid, called epoxydocosapentaenoic acids (EDPs), limit mitochondrial damage following cardiac injury. In particular, the 19,20-EDP regioisomer has demonstrated potent cardioprotective action. Thus, we...
-
Targeting Metabolic Dysregulation in Metabolic Dysfunction-Associated Steatotic Liver Disease
DownloadFall 2024
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition characterized by the accumulation of fat in the liver of persons who do not consume alcohol, commonly associated with metabolic dysregulation. MASLD is rising globally, particularly in Canada, impacting more than 7...
-
Development of Novel Models to Study Sub and Post Cellular Uptake of Drugs Following Oral Administration
DownloadFall 2024
Given the numerous benefits of oral administration, this thesis investigates two key phenomena influencing the pharmacokinetics and pharmacodynamics of orally administered active pharmaceutical ingredients (APIs): lysosomal trapping and intestinal lymphatic uptake via chylomicrons, with a...
-
Spring 2024
Comprehensive medication reviews provide an opportunity for patient-pharmacist dialogue and active patient participation in their care to identify and address their specific needs and concerns. Patient participation can contribute to positive patient experiences and high-quality care. However,...
-
Spring 2024
The conservation of ketone body metabolism across various domains of life, including eukaryotes, bacteria, and archaea, underscores its pivotal role in physiological processes. Primarily activated during carbohydrate scarcity, ketone body metabolism provides alternative energy, mainly to the...
-
Development of immuno and nano PET/SPECT probes: towards novel theranostics for EGFR positive solid tumors
DownloadFall 2024
Cancer continues to be a significant global public health issue, and regrettably, it remains one of the leading causes of death. Statistics indicate that 1 in 5 men or women will be diagnosed with cancer during their lifetime, resulting in 1 in 12 women and 1 in 9 men succumbing to the disease....
-
Exploring the Adoption of Point-of-care Testing for Acute Respiratory Infectious Diseases in Community Pharmacies
DownloadFall 2024
Background: Acute respiratory infectious diseases such as strep throat, influenza, and COVID-19 pose significant public health challenges. Community pharmacists in Canada have a broad scope of practice. They have been involved in assessing and prescribing for minor ailments, ordering laboratory...
-
Characterization of eNOS-based Platelets Subpopulations in COVID-19 and the Impact of Platelet α-Granule Contents on Cancer Cell PD-L1
DownloadFall 2024
Thrombosis significantly complicates numerous diseases that have inflammatory components. This condition, characterized by the formation of blood clots within blood vessels, can exacerbate a range of health issues, from cardiovascular diseases to systemic infections like COVID-19, and even...
-
Designing Nanomedicines for Breast Cancer Therapy: New Synthetic lipopolymers and Optimization of siRNA Formulations against Therapeutic Targets
DownloadFall 2024
In 2020, breast cancer became the most commonly diagnosed cancer worldwide. Conventional therapies like radiotherapy, chemotherapy and surgery have significant limitations and side effects that are mainly due to their inability to specifically target cancerous cells. Alternatively, gene therapy...
-
Modulation of Aryl Hydrocarbon Receptor (AHR)-Regulated Metabolic Enzymes by Arsenic Trioxide and its Thioarsenical Metabolite
DownloadFall 2024
Arsenic trioxide (ATOIII) has evolved into a successful therapy for acute promyelocytic leukemia (APL), however, being an arsenical, it retains at its core the hypertoxic characteristics of that notorious metalloid. Such inherent toxicity causes a constellation of complications in APL patients,...