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- 1Blood-brain barrier
- 1Intracerebral Hemorrhage
- 1Intracerebral hemorrhage
- 1Ion dyshomeostasis
- 1animal models
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Blood-brain barrier permeability following intracerebral hemorrhage is related to local ion dyshomeostasis
DownloadFall 2017
Background: Increased blood-brain barrier (BBB) permeability is seen after intracerebral hemorrhage (ICH). Following ICH, BBB dysfunction occurs due to direct (e.g. mechanical damage) and indirect (e.g. inflammation) injury. Damage to the BBB prevents maintenance of brain homeostasis. This thesis...
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Raised intracranial pressure and tissue compliance after large intracerebral hemorrhages in animal models and patients
DownloadFall 2022
Brain injuries that cause mass effect, including stroke and traumatic brain injury, can increase intracranial pressure (ICP) due to the limited space within the skull. Intracerebral hemorrhage (ICH) is a subtype of stroke in which there is bleeding in the brain. In cases of large bleeds, the...
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Spring 2021
Therapeutic hypothermia (TH) is a common intervention used in a variety of injury profiles. However, when applied to intracerebral hemorrhage (ICH), TH can worsen outcome. Previous research from our lab has shown that TH can aggravate intracranial bleeding both during cooling induction and...