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Skip to Search Results- 2Hegadoren, Kathleen M.
- 1Adu, Medard Kofi
- 1Al-Ghamdi,Mohammad S
- 1Al-Nuaimi, Saleem K
- 1Amritraj, Asha
- 1Amusan, Precious
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Spring 2017
Cannabis use is a known risk factor for the development of psychotic disorders. Clinical and preclinical genetic studies provide growing evidence that genes related to dopamine signalling and neuroprotection, like COMT, are implicated in the cannabis-psychosis association. Considering the burden...
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Variation in in vivo prefrontal GABA, glutamate and glutamine – effects of reproductive factors, cortisol and major depressive disorder
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Variations in glutamate and γ-aminobutyric acid (GABA), excitatory and inhibitory amino acid neurotransmitters in the brain, have been linked with cyclical changes across the menstrual cycle and in stress and stress-related mental disorders. We used 3.0 Tesla proton magnetic resonance...
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Non-verbal cognitive domain functions positively associate with mildly elevated fasting blood glucose in individuals presenting with a psychotic illness
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Background: The metabolic syndrome (MetS) is a cluster of biological parameters that have been identified as significant risk factors in the development of cardiovascular disease. The relevance of MetS to the psychiatric population has been demonstrated in that having severe mental illness (SMI)...
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Spring 2016
Schizophrenia is a complex neurodevelopmental illness that often requires a combination of treatments to adequately control its symptoms. Despite the availability of several neuroleptic medications on the market, many patients with schizophrenia remain symptomatic. Research has shifted...
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Adult Education to Help Reduce Child Sexual Abuse: Developing Novel Classroom and Online Approaches Designed to Change Knowledge, Attitudes, and Behaviours
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Child sexual abuse (CSA) is common and individuals who experience CSA have higher rates of psychopathology and higher risk of medical, psychological, behavioural, and sexual disorders than those who have not been sexually abused. Adults who interact with children are in ideal positions to reduce...
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Spring 2016
Depression is a common, recurrent and frequently chronic mental health disorder that has already become one of the leading health-care burdens. Despite the wide clinical application of antidepressants, a significant portion of patients does not benefit sufficiently from the standard medication...
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The Trauma and Attachment Group (TAG) program: An ethnographic exploration of an intensive dyad-based group intervention for traumatized youth
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The notion that positive relationships between primary caregivers and children may mitigate the behavioural effects of early developmental trauma has been well detailed in the literature. More specifically, it has been suggested that for a child managing the adverse effects of early developmental...
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Plasma Levels of Neuroactive Steroids in Panic Disorder Patients and Healthy Volunteers Following Pentagastrin versus Placebo Injections
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Panic disorder is an anxiety illness that can be quite debilitating and costly to society. To date there is no real cure for panic disorder and current methods of treatment are suboptimal. Given the level of morbidity and societal cost of panic disorder, further research and development of...
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Roles of the Insulin-like Growth Factor-II/Cation-independent Mannose 6-phosphate Receptor and Cathepsin D in Alzheimer’s Disease Pathology
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Alzheimer’s disease (AD) is the most common type of senile dementia affecting the elderly. A critical contributing factor to the neurodegeneration and development of AD pathology stems from the processing of amyloid precursor protein (APP), leading to the generation of β-amyloid (Aβ) peptides....
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Effect of Cholesterol Accumulation on the Metabolism of Amyloid Precursor Protein (APP) in Cultured N2a Cells
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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ) peptides derived from the proteolytic processing of amyloid precursor protein (APP). Accumulated evidence has shown that alterations in the levels and/or subcellular...