Search
Skip to Search Results- 2Hegadoren, Kathleen M.
- 1Al-Ghamdi,Mohammad S
- 1Al-Nuaimi, Saleem K
- 1Amritraj, Asha
- 1Amusan, Precious
- 1Armstrong, Jeff
-
Novel properties of the multifaceted drug phenelzine and its metabolite β-phenylethylidenehydrazine
DownloadFall 2015
Phenelzine is a monoamine oxidase (MAO) inhibitor that has been used for the treatment of depression and anxiety disorders since the 1960s. In recent years, there has been renewed interest in this drug following reports of its neuroprotective properties in animal models of cerebral ischemia,...
-
Delineating the Relationship between Self-Trust and Generalized Self-Efficacy: Implications for Mental Health
DownloadFall 2014
Generalized self-efficacy (GSE) is understood as a stable and trait-like belief that one can manage challenging situations or tasks one is faced with. Based on Bandura’s social cognitive theory, GSE is thought to arise from repeated experiences of mastery and performance success over a broad...
-
Fall 2014
Gambling is a recreational activity enjoyed by many; however, for some this enjoyment can lead to the development of Gambling Disorder with financial, personal, and psychological ramifications. The study of pathological gamblers has targeted the psychological, behavioural and neurobiological...
-
Spring 2014
Major depression (MD) is one of the most prominent medical conditions worldwide in terms of societal cost and morbidity. MD has been associated with increased risk for cardiovascular disease (CVD) and conversely CVD has been associated with increased MD symptoms. Previous studies have shown that...
-
Fall 2014
Prescription of high dose antipsychotics remains a common practice, contrary to available evidence. Studies have found that, on average, high daily doses of antipsychotics are no more effective or are less effective than are moderate doses, and have indicated that higher doses are associated with...
-
Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 protein
DownloadSpring 2013
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
-
The Antidepressant/Antipanic/Neuroprotective Drug Phenelzine: Neuropharmacological and Drug Metabolism Studies
DownloadSpring 2013
Phenelzine (PLZ) is a monoamine oxidase (MAO)-inhibiting antidepressant with anxiolytic and neuroprotective properties. Metabolites of PLZ were investigated in rat brain. Levels of phenylacetic acid (PAA) and β-phenylethylamine (PEA) were found to be elevated after administration of PLZ and PEH...
-
Fall 2013
Individuals with human immunodeficiency virus (HIV) develop neurocognitive impairments, more frequently as the systemic disease progresses to AIDS. Among HIV-infected persons receiving antiretroviral therapy, executive dysfunctions are very commonly impaired. The present study examined...
-
Fall 2013
Cognitive deficits affect approximately 50% of multiple sclerosis (MS) patients and are associated with disease-related neurodegeneration. Prior MS-studies found decision making impairments uncorrelated with patients’ cognitive functions. Brain correlates of decision making in MS have not been...
-
Spring 2012
The association between stimulant drug use and the presence of a psychotic disorder raises questions about causation. Substance-induced psychosis may differ etiologically from schizophrenia despite similar phenotypic presentation. It is possible that stimulant drug users who develop symptoms of...