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Skip to Search Results- 2Muller, Milan J.
- 1Abeywardena, Mahinda Yapa
- 1Abou-Chehade, Kassim D.
- 1Adjei, Alex Asiedu.
- 1Al-Majed, Abdulhakeem A
- 1Ali, Mohammad M. A.
- 5Rats as laboratory animals.
- 4GABA. Receptors.
- 4Metalloproteinases. Physiological effect.
- 4Pharmacology
- 3Adenosine
- 3Autophagy
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Role of matrix metalloproteinase-2 in sarcoplasmic reticulum dysfunction during myocardial ischemia-reperfusion injury
DownloadSpring 2019
Matrix metalloproteinase-2 (MMP-2) is an intra- and extra-cellular protease which is activated during myocardial ischemia-reperfusion (IR) injury by reactive oxygen and nitrogen species, namely peroxynitrite. Upon its activation, MMP-2 impairs cardiac contractility by cleaving sarcomeric and...
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Spring 2022
Pancreatic β-cells are paramount for optimizing insulin secretion to metabolic need. The progression from non-diabetes to type 2 diabetes (T2D) is accompanied by β-cell compensation and decompensation. While β-cell decompensation is a hallmark of overt diabetes, β-cell compensation promotes...
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Sex Differences in Central Nervous System Plasticity and Pain in Experimental Autoimmune Encephalomyelitis
DownloadSpring 2019
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease with many known structural and functional changes in the central nervous system (CNS). A well-recognized, but poorly understood, complication of MS is chronic pain. Little is known regarding the influence of sex on the development...
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Short-term Calorie Restriction Improves Post-ischemic Recovery in the Spontaneously Hypertensive Rat
DownloadFall 2012
Ischemic heart disease is the leading cause of death in Western countries. We demonstrated how alterations in energy metabolism and the activation of Reperfusion Injury Salvage Kinase (RISK) pathway induced by short-term calorie restriction (CR) contribute to protecting the diseased heart from...
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Fall 2017
Protein prenylation is the post-translational addition of isoprenoid lipid moieties to proteins, which regulates their subcellular localization and function. Farnesyl or geranylgeranyl isoprenoids are covalently linked to cysteines residues in a C-terminal prenylation recognition sequence in...
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Structure-Affinity Relationship Study of Novel Imidazoline Ligands at Imidazoline Binding Sites and α-Adrenoceptors
DownloadFall 2014
Many drugs containing an imidazoline moiety are thought to bind to both imidazoline binding sites (IBS) and α-adrenoceptors (α-AR) to mediate their therapeutic effects. To aid in better characterisation of these binding sites, the structure-affinity relationships of several new series of...