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Skip to Search Results- 2Muller, Milan J.
- 1Abeywardena, Mahinda Yapa
- 1Abou-Chehade, Kassim D.
- 1Adjei, Alex Asiedu.
- 1Al-Majed, Abdulhakeem A
- 1Ali, Mohammad M. A.
- 5Rats as laboratory animals.
- 4GABA. Receptors.
- 4Metalloproteinases. Physiological effect.
- 4Pharmacology
- 3Adenosine
- 3Autophagy
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Fall 2012
Despite originally being described as a secreted protease, matrix metalloproteinase‐2 (MMP‐2) was recently revealed to have targets within cardiomyocytes. The biological mechanism(s) that describes the intracellular localization of MMP‐2 is unknown and is thus the subject of this thesis....
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Fall 2019
Matrix metalloproteinase-2 (MMP-2) is a zinc-dependent protease that proteolyzes numerous substrates both inside and outside the cell when activated during oxidative stress. However, the full gamut of MMP-2 substrates in myocardial oxidative stress injury is largely unknown. This thesis...
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Fall 2015
Youssef, Nermeen Hosny Ibrahim
Plasma membrane ATP-sensitive potassium (KATP) channels are found in many excitable cell types where they couple cellular metabolism and membrane excitability. . Studies on KATP deficient mice show that parameters of cardiac mechanical function are similar to those of wild-type mice under basal...
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Nuclear matrix metalloproteinase-2 and investigation of its potential targets in myocardial ischemia-reperfusion injury
DownloadSpring 2016
Matrix metalloproteinases (MMPs) are zinc-dependent proteases involved in intra- and extra-cellular matrix remodeling. MMP-2 was the first to be localized to the nucleus; however the biological functions and substrates of nuclear MMP-2 are mostly unknown. We hypothesized that...
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Spring 2016
Stress generates an adaptive behavioral and physiological response that prepares an organism for new environmental pressures. However, if stressors are perceived as uncontrollable, prolonged, or severe, they can produce exaggerated responses and result in neuropsychiatric syndromes such as...
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Spring 2019
Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance and an insufficiency of insulin secretion from the pancreatic β cell. The incidence of T2DM is rising worldwide at an alarming rate. Increased prevalence of obesity is a major contributor to this rise in T2DM...