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Skip to Search Results- 2Coulombe, Marilyne G.
- 2Kinnaird, Adam
- 2Srivastava, Nutan
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Aburahess, Salah
- 8Primary Biliary Cholangitis
- 7Inflammatory bowel disease
- 6Inflammatory Bowel Disease
- 5Acute myeloid leukemia
- 5Endothelial cells
- 4B cells
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Unveiling the pathway for the nuclear translocation of the large mitochondrial enzyme Pyruvate Dehydrogenase Complex (PDC)
DownloadSpring 2021
Pyruvate dehydrogenase complex (PDC) is a mitochondrial enzyme that links glycolysis to oxidative phosphorylation by decarboxylating glucose-derived pyruvate to produce acetyl-CoA that is used in the Krebs cycle. PDC was initially thought to reside only in the mitochondrial matrix but we recently...
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A Reversible Metabolic Stress-Sensitive Regulation of Collapsin Response Mediator Protein 2A Orchestrates Cytoskeletal Remodeling and EMT, Increasing Metastatic Potential in Cancer
DownloadFall 2021
Cancer represents the second leading cause of death globally only after heart disease and is responsible for about 10 million deaths per year with a significant economic impact (WHO facts). Moreover, its prevalence is projected to increase over the following decades. Among all cancers, breast,...
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Spring 2021
Al-Karaghouli, Mustafa Thaier Salman
Background and Rationale The degree of fibrosis in nonalcoholic fatty liver disease (NAFLD) determines the risk of liver complications. Non-invasive tests (NITs) such as FIB-4, NFS and Hepamet, have been proposed to triage patients in primary care (PC) for further assessment due to their high...
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Fall 2021
Computed Tomography Perfusion (CTP) is a rapidly acquired minimally invasive mean to assess brain perfusion dynamics, collaterals and infarct growth in acute ischemic stroke (AIS). It helps differentiate expected stroke evolution and speed of core growth after arterial occlusion. The goals of...
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Fall 2021
Background Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL). Early stage disease, limited to skin patches & plaques, is indolent. However, progression to tumour stage disease marks a significant drop in survival to less than 4 years. Treatments for advanced disease are...
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Spring 2021
The nuclear transcription factor, Signal Transducer and Activator of Transcription 5 (STAT5) is one of the key drivers of Acute Lymphoblastic Leukemia (ALL), the most common childhood cancer, that promotes initiation, maintenance and progression to more aggressive stages of the malignancy by...
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Cytoskeletal Remodeling and Exocytosis During Mast Cell Activation is Controlled by the RhoA GEF, GEF-H1
DownloadFall 2021
Mast cells are tissue-resident immune cells that play important roles in health and diseases. Mast cells release their granule contents under antigen-stimulation via the FcεRI signaling pathway. The process of regulated exocytosis in mast cells is known as degranulation which participates in...
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Spring 2021
Decision-making is required for daily living. Specific decision-making ability in the area of finances is complex, and determining an individual’s capacity requires an in-depth assessment. In the presence of communication disorders such as aphasia, such assessments can become challenging, and...
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Severe cholestasis during the first year post-transplant predicts primary sclerosing cholangitis recurrence
DownloadFall 2021
Background Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic disease of unknown etiology, whose only definitive management is liver transplantation. One of the dilemmas that PSC patients face is the recurrence of the disease in the graft, which may shorten the organ’s life expectancy...
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Immune activation in patients with admission blood pressure above 185/110 mm Hg in acute ischemic stroke
DownloadFall 2021
Background: An admission blood pressure over 185/110 mm Hg is associated with increased risk of recombinant tissue plasminogen activator (r-tPA)-related hemorrhagic transformation (HT). Stroke guidelines recommend blood pressure (BP) above 185/110 mm Hg be lowered before r-tPA treatment. How high...