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Fall 2021

Batool, Yusra

Background: An admission blood pressure over 185/110 mm Hg is associated with increased risk of recombinant tissue plasminogen activator (r-tPA)-related hemorrhagic transformation (HT). Stroke guidelines recommend blood pressure (BP) above 185/110 mm Hg be lowered before r-tPA treatment. How high...

Fall 2021

Guo, Yitian

Mast cells are tissue-resident immune cells that play important roles in health and diseases. Mast cells release their granule contents under antigen-stimulation via the FcεRI signaling pathway. The process of regulated exocytosis in mast cells is known as degranulation which participates in...

Fall 2021

Sivanand, Arunima

Background Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL). Early stage disease, limited to skin patches & plaques, is indolent. However, progression to tumour stage disease marks a significant drop in survival to less than 4 years. Treatments for advanced disease are...

Spring 2021

Zervopoulos, Sotirios

Pyruvate dehydrogenase complex (PDC) is a mitochondrial enzyme that links glycolysis to oxidative phosphorylation by decarboxylating glucose-derived pyruvate to produce acetyl-CoA that is used in the Krebs cycle. PDC was initially thought to reside only in the mitochondrial matrix but we recently...

Spring 2020

Heffernan, Courtney

Pulmonary tuberculosis (TB) is a communicable disease that has an airborne route of transmission. It is a disease of poverty that exists in every country of the world. Within high-income, low TB burden settings, the disease increasingly affects vulnerable and underserved population groups who are...

Fall 2020

Lingyu Xu

Heart failure (HF) is a progressive and complex syndrome with poor prognosis, characterized by a wide array of cardiac structural and functional abnormalities. Patients are typically categorized according to left ventricular ejection fraction (LVEF), with reduced ejection fraction defined as...

Spring 2020

Chiang Jurado, Diana Alejandra

Background: Vancomycin-resistant Enterococci (VRE) colonization is common in liver transplant candidates. In addition to the risk of invasive enterococcal infections, dominance of VRE colonization in the gut may contribute to low microbiota diversity playing a role in the transplant outcomes. The...

Spring 2020

Sutton, Reed T

Clinical care pathways have been developed with the goal to standardize and improve quality of care. At the University of Alberta, clinical care pathways have been developed, and are currently in use, for inflammatory bowel disease patents experiencing disease flare. However, there is limited...

Fall 2020

Jackson, Marcus

This thesis examines the role of community completeness in the health and wellbeing of older adults. Community completeness is a concept commonly used in urban planning policies by cities, however utilizations and definitions vary between locations. As the older adult population in Canada and...

Spring 2020

Iyer, Aishwarya

Cutaneous T-cell lymphoma (CTCL) is heterogeneous form of T-cell lymphoma of which, Mycosis fungoides (MF) is the most common entity. In early stages MF presents on skin as a scaly plaques that in advanced stages develop into tumors and may disseminate to other sites such as lymph node and...