Search
Skip to Search Results- 2Coulombe, Marilyne G.
- 2Logus, J. Wayne (John Wayne), 1951-
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Agrawal, Amogh
- 1Ahmed, Iqbal Hussein, 1953-
- 7Primary Biliary Cholangitis
- 6Inflammatory bowel disease
- 5Inflammatory Bowel Disease
- 4B cells
- 4Depression
- 4Endothelial cells
-
Fall 2021
Primary Biliary Cholangitis (PBC) is a complex cholestatic liver disorder with both environmental and genetic factors that contribute to disease. While the etiology remains poorly understood, our lab continues to characterize the role of a human betaretrovirus (HBRV) in the disease process. Based...
-
Investigating the role of G-protein coupled receptor (GPCR) signaling as a potential target for anti-angiogenic therapy
DownloadFall 2021
Angiogenesis is an essential process for normal growth and development whereby new blood vessels are formed from pre-existing ones. The balance between pro-angiogenic and anti-angiogenic growth factors is critical to maintain normal physiological condition. Prolonged activation of angiogenesis...
-
Fall 2021
Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic liver disease with unknown etiology that is characterized by inflammation and fibrosis of the intrahepatic and extrahepatic biliary tracts, leading to diffuse multifocal stricture formation. The pathogenesis of PSC is...
-
Immune activation in patients with admission blood pressure above 185/110 mm Hg in acute ischemic stroke
DownloadFall 2021
Background: An admission blood pressure over 185/110 mm Hg is associated with increased risk of recombinant tissue plasminogen activator (r-tPA)-related hemorrhagic transformation (HT). Stroke guidelines recommend blood pressure (BP) above 185/110 mm Hg be lowered before r-tPA treatment. How high...
-
Cytoskeletal Remodeling and Exocytosis During Mast Cell Activation is Controlled by the RhoA GEF, GEF-H1
DownloadFall 2021
Mast cells are tissue-resident immune cells that play important roles in health and diseases. Mast cells release their granule contents under antigen-stimulation via the FcεRI signaling pathway. The process of regulated exocytosis in mast cells is known as degranulation which participates in...
-
Fall 2021
Background Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL). Early stage disease, limited to skin patches & plaques, is indolent. However, progression to tumour stage disease marks a significant drop in survival to less than 4 years. Treatments for advanced disease are...
-
Spring 2021
Al-Karaghouli, Mustafa Thaier Salman
Background and Rationale The degree of fibrosis in nonalcoholic fatty liver disease (NAFLD) determines the risk of liver complications. Non-invasive tests (NITs) such as FIB-4, NFS and Hepamet, have been proposed to triage patients in primary care (PC) for further assessment due to their high...
-
Fall 2021
Computed Tomography Perfusion (CTP) is a rapidly acquired minimally invasive mean to assess brain perfusion dynamics, collaterals and infarct growth in acute ischemic stroke (AIS). It helps differentiate expected stroke evolution and speed of core growth after arterial occlusion. The goals of...
-
Spring 2021
Decision-making is required for daily living. Specific decision-making ability in the area of finances is complex, and determining an individual’s capacity requires an in-depth assessment. In the presence of communication disorders such as aphasia, such assessments can become challenging, and...
-
Severe cholestasis during the first year post-transplant predicts primary sclerosing cholangitis recurrence
DownloadFall 2021
Background Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic disease of unknown etiology, whose only definitive management is liver transplantation. One of the dilemmas that PSC patients face is the recurrence of the disease in the graft, which may shorten the organ’s life expectancy...