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Skip to Search Results- 2Coulombe, Marilyne G.
- 2Logus, J. Wayne (John Wayne), 1951-
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Agrawal, Amogh
- 1Ahmed, Iqbal Hussein, 1953-
- 7Primary Biliary Cholangitis
- 6Inflammatory bowel disease
- 5Inflammatory Bowel Disease
- 4B cells
- 4Depression
- 4Endothelial cells
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Fall 2022
Heart transplantation (HTx) is a life-saving intervention for patients with end-stage heart failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the longevity of transplanted cardiac allografts and the survival of recipients. The pathogenesis of CAV begins with a...
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Automated Insulin Delivery System Use in Canada: Incorporating Perspectives of Both Users and Healthcare Providers
DownloadFall 2022
An Automated Insulin Delivery (AID) system combines an insulin pump and glucose sensor, with utilization of a computerized predictive algorithm, to enable automated adjustment in insulin delivery rate. Do-it-Yourself (DIY) or Open-source AID systems were the first form of this technology...
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The association between access to medical care (physicians and nurse practitioners) and impact on resident outcomes: A retrospective cross-sectional analysis
DownloadSpring 2022
The nursing home population is vulnerable and medically complex, yet little is known about models of medical service provision and associated quality outcomes. The goal of this thesis project is to examine the association between physician and nurse practitioner accessibility and practice...
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Evaluation of Frailty Assessment Tools and their Measurement Properties in Chronic Kidney Disease
DownloadSpring 2022
Background: Frailty is three to seven times more common in people with chronic kidney disease (CKD) than in those with normal kidney function. Although frailty and its impact in CKD is well-recognized, the measurement properties of the tools used to assess this syndrome are not known. The aim of...
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Spring 2022
Allergens possessing serine proteinase activity like house dust mite (HDM) and cockroach can activate proteinase-activated receptor-2 (PAR-2), a pro-inflammatory G-coupled receptor. Par-2 -/- mice develop attenuated airway inflammation compared to WT mice. PAR-2 blockage in the airways abrogated...
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The perplexity of calcium-binding protein, spermatid-associated 1 (CABS1): A molecule that despite its name, is present beyond the reproductive tract, with ties to stress, and possessing an anti-inflammatory domain only preserved in simians
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A protein in rat submandibular glands (SMG) led our group to research human calcium-binding protein, spermatid associated 1 (CABS1). In a model of lung inflammation in rats where neural input was interrupted, our group observed that SMG released an anti-inflammatory factor later identified as...
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Investigating the role of G-protein coupled receptor (GPCR) signaling as a potential target for anti-angiogenic therapy
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Angiogenesis is an essential process for normal growth and development whereby new blood vessels are formed from pre-existing ones. The balance between pro-angiogenic and anti-angiogenic growth factors is critical to maintain normal physiological condition. Prolonged activation of angiogenesis...
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Fall 2021
Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic liver disease with unknown etiology that is characterized by inflammation and fibrosis of the intrahepatic and extrahepatic biliary tracts, leading to diffuse multifocal stricture formation. The pathogenesis of PSC is...
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Immune activation in patients with admission blood pressure above 185/110 mm Hg in acute ischemic stroke
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Background: An admission blood pressure over 185/110 mm Hg is associated with increased risk of recombinant tissue plasminogen activator (r-tPA)-related hemorrhagic transformation (HT). Stroke guidelines recommend blood pressure (BP) above 185/110 mm Hg be lowered before r-tPA treatment. How high...
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Cytoskeletal Remodeling and Exocytosis During Mast Cell Activation is Controlled by the RhoA GEF, GEF-H1
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Mast cells are tissue-resident immune cells that play important roles in health and diseases. Mast cells release their granule contents under antigen-stimulation via the FcεRI signaling pathway. The process of regulated exocytosis in mast cells is known as degranulation which participates in...