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Skip to Search Results- 2Coulombe, Marilyne G.
- 2Logus, J. Wayne (John Wayne), 1951-
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Agrawal, Amogh
- 1Ahmed, Iqbal Hussein, 1953-
- 7Primary Biliary Cholangitis
- 6Inflammatory bowel disease
- 5Inflammatory Bowel Disease
- 4B cells
- 4Depression
- 4Endothelial cells
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Investigating Primary Biliary Cholangitis for a Human Betaretrovirus Superantigen signature
DownloadSpring 2022
Primary Biliary Cholangitis (PBC) is an idiopathic autoimmune disease characterized by destruction of small hepatic bile ducts and presence of antimitochondrial antibodies (AMA). A Human Betaretrovirus (HBRV) sharing 91-99% sequence similarity with the Mouse Mammary Tumor virus has been...
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Identification of Natural Health Product-Associated Adverse Events and Natural Health Product-Drug Interactions in Adults and Children with Cancer
DownloadSpring 2022
Background: Patients with cancer frequently use natural health products (NHPs) to help treat cancer, reduce side effects, or improve effectiveness of conventional cancer treatment, and improve their quality of life. Often oncology healthcare providers do not inquire about NHP use, leading to low...
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Spring 2022
The endomembrane system is one of the hallmark features of all eukaryotes that distinguishes them from prokaryotes. Compared to bacteria and archaea, eukaryotic cells consist of biochemically and functionally distinct membranous compartments such as the endoplasmic reticulum, the Golgi apparatus,...
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Exploring the Association Between Frailty and Adverse Clinical Outcomes in Inflammatory Bowel Disease
DownloadFall 2022
Background and Rationale: Chronological age does not always accurately reflect “biological age”, or the extent of physiological reserve an individual possesses to endure stressors. The concept of physiological reserve is best represented by frailty; a multifaceted syndrome or state that...
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Management of alcohol use disorder in cirrhosis: effect of a clinician-targeted alcohol use disorder in cirrhosis educational intervention on knowledge, attitudes, and practice habits
DownloadFall 2022
Introduction: Alcohol use disorder (AUD) is a common cause of liver cirrhosis. Low knowledge and comfort managing AUD among well-intentioned clinicians impacts the number of patients with cirrhosis who receive AUD treatment. Structured education focused on screening, brief intervention, referral...
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Fall 2022
Background Muscular dystrophy (MD) is a group of inherited neuromuscular disorders with heart disease as a leading cause of morbidity and mortality. Dystrophinopathies such as Duchenne and Becker MD, limb-girdle MD, type 1 myotonic dystrophy (DM1), and facioscapulohumeral MD are most associated...
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Fall 2022
Background The discovery of angiotensin-converting enzyme 2 (ACE2) introduced an alternative protective arm of the renin-angiotensin system (RAS), the ACE2/Angiotensin 1-7 (Ang 1-7)/Mas receptor axis, to counterbalance the more renowned pathogenic angiotensin-converting enzyme (ACE)/Angiotensin...
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Fall 2022
Heart transplantation (HTx) is a life-saving intervention for patients with end-stage heart failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the longevity of transplanted cardiac allografts and the survival of recipients. The pathogenesis of CAV begins with a...
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Automated Insulin Delivery System Use in Canada: Incorporating Perspectives of Both Users and Healthcare Providers
DownloadFall 2022
An Automated Insulin Delivery (AID) system combines an insulin pump and glucose sensor, with utilization of a computerized predictive algorithm, to enable automated adjustment in insulin delivery rate. Do-it-Yourself (DIY) or Open-source AID systems were the first form of this technology...
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Understanding Heart Failure in Patients with Dilated Cardiomyopathy: A Direct Tissue Analysis from Explanted Human Hearts
DownloadFall 2022
Background Chronic heart failure (HF) remains a rising global epidemic that affects both adults and children population. The causes of HF are heterogeneous, and syndromes are often complicated by concomitant disorders such as iron deficiency (ID) and diabetes. Comorbidities not only complicate...