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Combined Assembly of Metagenomic Libraries from The Faecal Samples of IBD and PSC Patients Allowed The Identification of African Swine Fever Virus-like Sequences
DownloadSpring 2015
Metagenomics is an emerging discipline to explore microbial diversity in clinical samples, independent of the limitations of cell cultures. This method is widely accepted as a modern technique to detect novel viruses in clinical and environmental samples and has the potential to contribute to the...
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Investigating Primary Biliary Cholangitis for a Human Betaretrovirus Superantigen signature
DownloadSpring 2022
Primary Biliary Cholangitis (PBC) is an idiopathic autoimmune disease characterized by destruction of small hepatic bile ducts and presence of antimitochondrial antibodies (AMA). A Human Betaretrovirus (HBRV) sharing 91-99% sequence similarity with the Mouse Mammary Tumor virus has been...
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Fall 2021
Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic liver disease with unknown etiology that is characterized by inflammation and fibrosis of the intrahepatic and extrahepatic biliary tracts, leading to diffuse multifocal stricture formation. The pathogenesis of PSC is...
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Severe cholestasis during the first year post-transplant predicts primary sclerosing cholangitis recurrence
DownloadFall 2021
Background Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic disease of unknown etiology, whose only definitive management is liver transplantation. One of the dilemmas that PSC patients face is the recurrence of the disease in the graft, which may shorten the organ’s life expectancy...
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The Detection of Antibodies against Human Betaretrovirus Surface Protein in Patients with Primary Biliary Cirrhosis
DownloadSpring 2015
Introduction: Primary biliary cirrhosis is an autoimmune liver disease in which cellular and humoral immune responses towards cholangiocytes cause progressive intrahepatic bile duct loss. Cholestasis, liver fibrosis, and eventually cirrhosis result, with liver transplantation or death occurring...