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Skip to Search Results- 2Coulombe, Marilyne G.
- 2Logus, J. Wayne (John Wayne), 1951-
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Agrawal, Amogh
- 1Ahmed, Iqbal Hussein, 1953-
- 7Primary Biliary Cholangitis
- 6Inflammatory bowel disease
- 5Inflammatory Bowel Disease
- 4B cells
- 4Depression
- 4Endothelial cells
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Spring 2022
Allergens possessing serine proteinase activity like house dust mite (HDM) and cockroach can activate proteinase-activated receptor-2 (PAR-2), a pro-inflammatory G-coupled receptor. Par-2 -/- mice develop attenuated airway inflammation compared to WT mice. PAR-2 blockage in the airways abrogated...
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The association between access to medical care (physicians and nurse practitioners) and impact on resident outcomes: A retrospective cross-sectional analysis
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The nursing home population is vulnerable and medically complex, yet little is known about models of medical service provision and associated quality outcomes. The goal of this thesis project is to examine the association between physician and nurse practitioner accessibility and practice...
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Evaluation of Frailty Assessment Tools and their Measurement Properties in Chronic Kidney Disease
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Background: Frailty is three to seven times more common in people with chronic kidney disease (CKD) than in those with normal kidney function. Although frailty and its impact in CKD is well-recognized, the measurement properties of the tools used to assess this syndrome are not known. The aim of...
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The perplexity of calcium-binding protein, spermatid-associated 1 (CABS1): A molecule that despite its name, is present beyond the reproductive tract, with ties to stress, and possessing an anti-inflammatory domain only preserved in simians
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A protein in rat submandibular glands (SMG) led our group to research human calcium-binding protein, spermatid associated 1 (CABS1). In a model of lung inflammation in rats where neural input was interrupted, our group observed that SMG released an anti-inflammatory factor later identified as...
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Understanding Heart Failure in Patients with Dilated Cardiomyopathy: A Direct Tissue Analysis from Explanted Human Hearts
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Background Chronic heart failure (HF) remains a rising global epidemic that affects both adults and children population. The causes of HF are heterogeneous, and syndromes are often complicated by concomitant disorders such as iron deficiency (ID) and diabetes. Comorbidities not only complicate...
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Fall 2022
Background: Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease featuring beta-amyloid deposits within the cerebral vasculature. It is a major cause of cognitive decline and intracerebral hemorrhage in the elderly. A gap in knowledge surrounding mechanisms underlying CAA...
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The Development, Feasibility, Acceptability, and Efficacy of a 12-Week Online Mind-Body Intervention for People with Primary Biliary Cholangitis
DownloadFall 2022
Introduction: Persons with primary biliary cholangitis (PBC) experience significantly higher rates of mental distress, impaired health related quality of life (HrQoL), and fatigue than the general population. While mind-body interventions have been shown to improve mental health and HrQoL, and...
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Spring 2022
The endomembrane system is one of the hallmark features of all eukaryotes that distinguishes them from prokaryotes. Compared to bacteria and archaea, eukaryotic cells consist of biochemically and functionally distinct membranous compartments such as the endoplasmic reticulum, the Golgi apparatus,...
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Identification of Natural Health Product-Associated Adverse Events and Natural Health Product-Drug Interactions in Adults and Children with Cancer
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Background: Patients with cancer frequently use natural health products (NHPs) to help treat cancer, reduce side effects, or improve effectiveness of conventional cancer treatment, and improve their quality of life. Often oncology healthcare providers do not inquire about NHP use, leading to low...
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Investigating Primary Biliary Cholangitis for a Human Betaretrovirus Superantigen signature
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Primary Biliary Cholangitis (PBC) is an idiopathic autoimmune disease characterized by destruction of small hepatic bile ducts and presence of antimitochondrial antibodies (AMA). A Human Betaretrovirus (HBRV) sharing 91-99% sequence similarity with the Mouse Mammary Tumor virus has been...