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Examination of the Regulation of Phosphorylation Events in Macrophage Adhesion and Response to Zymosan
DownloadFall 2012
Macrophages play a central role in innate immunity, most notably in tissue repair, phagocytosis of dead or infected cells, secretion of chemokine and cytokines at sites of infection, as well as the activation of other immune cells. These roles are highly dependent on their capacity to migrate...
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Intracellular expression of Fas Ligand and Granzyme B by tumor infiltrating or in vitro activated CD8+ T cell populations
DownloadSpring 2019
CD8+ T cells can recognize infected or cancerous cells and eliminate them by exocytosing cytolytic molecules or presenting death ligands on their surface, both of which can initiate apoptosis in target cells. Granzyme B (GzmB) and Fas Ligand (FasL) are two of the effector proteins that CD8+ T...
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Localization and Trafficking of the Death-Inducing Fas Ligand Protein in Cytotoxic T Lymphocytes
DownloadFall 2014
Cytotoxic T lymphocytes (CTL) can kill tumor cells and cells infected with intracellular pathogens. Their two major killing mechanisms are the degranulation pathway and the Fas-FasL pathway. The degranulation process consists of the release of cytolytic perforin and granzyme molecules that are...
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Molecular Regulation and Function of the Protein Tyrosine Kinase Pyk2 in Cytotoxic T Lymphocytes
DownloadFall 2013
Cytotoxic T lymphocytes (CTL) play a critical role in immune surveillance and elimination of virus-infected and malignant cells. CTL utilize two major cell-contact dependent mechanisms to kill antigen-bearing target cells. One mechanism involves the directional release of cytolytic molecules...
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Fall 2009
Cytotoxic T lymphocytes (CTL) are differentiated CD8+ T cells that eliminate virally infected cells and tumor cells. CTL lyse target cells by at least two distinct mechanisms: degranulation of cytolytic molecules and cell surface expression of Fas ligand (FasL), which induces apoptosis of...