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Examination of the roles of the AP-1 transcription factors, JunB and c-Jun, in the pathobiology of Anaplastic Lymphoma Kinase-positive, Anaplastic Large Cell Lymphoma (ALK+ ALCL)
DownloadSpring 2019
Anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is an aggressive T cell lymphoma that is characterized by chromosomal translocations involving the gene encoding for the ALK tyrosine kinase. The ALK fusion proteins generated through these translocations initiate...
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Spring 2013
The activation of caspases is an important step not only in apoptosis induction, but in cellular processes such as proliferation, differentiation, and the immune response. Here, we show that the AP-1 family transcription factor JunB is cleaved and dephosphorylated in a caspase-dependent manner in...
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Investigating the functions and interactions of Salmonella effector SspH2 with intracellular innate immune receptors
DownloadFall 2021
As part of its pathogenesis, Salmonella enterica serovar typhimurium delivers effector proteins into host cells. One such effector is SspH2, a member of the novel E3 ubiquitin ligase (NEL) family, which has been reported to interact with, and enhance, NOD1 pro-inflammatory signaling. It is still...
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Investigating the functions of the c-Jun and JunB transcription factors in classical Hodgkin Lymphoma
DownloadFall 2016
Classical Hodgkin lymphoma (cHL) is characterized by the presence of abnormal mononuclear Hodgkin and multinuclear Reed-Sternberg (HRS) cells, which are thought to be derived from clonally expanded germinal center B cells. The tumour cells have been demonstrated to have various signalling...
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Understanding the function of the JunB transcription factor in anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma
DownloadFall 2013
Anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is a non-Hodgkin lymphoma thought to arise from an activated T lymphocyte. This lymphoma is characterized by the presence of chromosomal translocations involving the ALK tyrosine kinase, which generate oncogenic...