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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Airo, Adriana M
- 1Arendt, Christopher William.
- 1Awadh, Abdullah
- 1Azaizeh, Bara'ah
- 1Bacik, John-Paul
- 8Evans, David (Medical Microbiology and Immunology)
- 5Barry, Michele (Medical Microbiology and Immunology)
- 5Foley, Edan (Medical Microbiology and Immunology)
- 5Ingham, Robert (Medical Microbiology and Immunology)
- 5Ostergaard, Hanne (Medical Microbiology and Immunology)
- 3Baldwin, Troy (Medical Microbiology and Immunology)
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The role of obesity and insulin resistance in modulating immune cell function in cancer and liver disease
DownloadFall 2023
Obesity and associated insulin resistance (IR) represent a significant global health burden, and predispose individuals to develop various diseases, including cancer and liver diseases. Heightened inflammation during obesity can on the one hand exacerbate liver inflammation, while on the other,...
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Investigating the role of the base mismatches within the hairpin ends of vaccinia virus genome in viral life cycle
DownloadSpring 2023
The genome of poxviruses consists of a double-stranded DNA that is flanked by two AT-rich hairpin ends encoding mismatched nucleotides. These mismatched structures are composed of incompletely base paired regions forming extra-helical loops. Though the functionality of these mismatches has not...
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Fall 2023
The intestinal epithelium is a complex tissue monolayer composed of regionally and functionally specialized cells. Given epithelial exposure to harsh and varied luminal conditions, epithelial cells continuously regenerate to sustain the barrier against environmental factors, including microbial...
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Spring 2022
Positive strand RNA ((+)ssRNA) viruses are some of the most important pathogens that impact the public health, economy, and quality of life. The interferon (IFN) response plays a critical role in innate immune response targeting (+)ssRNA viruses, which in turn have evolved various strategies to...
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Investigating the differential effects of LILRB1 natural variants on interaction with MHC-I and UL18
DownloadFall 2022
The Leukocyte immunoglobulin-like receptor B1 (LILRB1) is widely expressed throughout human immune cells of lymphoid and myeloid origins. It is also associated with viral infection, autoimmune diseases and cancer. LILRB1 regulates immune responses through broad interaction with major...
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Spring 2022
Dendritic cells (DCs) are antigen presenting cells critical for the initiation of the adaptive immune response. As such, DCs continually circulate the body to survey for foreign antigen in the periphery. DCs encounter a milieu of environmental cues within the traversed microenvironment that can...
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Fall 2022
Zika virus (ZIKV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are important emerging human pathogens that have disrupted global health. More therapeutic and prophylactic treatments for the diseases caused by the emerging viruses are needed. Expansion of our knowledge on the...
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Investigating and characterizing the direct binding interactions between chemotherapeutic cisplatin and pattern recognition receptor, Toll-like Receptor 4
DownloadFall 2022
Cisplatin is one of the most effective chemotherapeutic agents available. Unfortunately, adverse drug reactions - cisplatin-induced toxicities - often limit the use of cisplatin. These toxicities develop in at least half of those treated, are diverse, and are especially problematic for pediatric...
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Investigating the functions and interactions of Salmonella effector SspH2 with intracellular innate immune receptors
DownloadFall 2021
As part of its pathogenesis, Salmonella enterica serovar typhimurium delivers effector proteins into host cells. One such effector is SspH2, a member of the novel E3 ubiquitin ligase (NEL) family, which has been reported to interact with, and enhance, NOD1 pro-inflammatory signaling. It is still...
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Characterization of the crosstalk between immunity and metabolism in Drosophila melanogaster model
DownloadFall 2021
Immune and metabolic pathways collectively contribute to the containment of microbial invaders, and persistent activation of immune responses contribute to the development of severe metabolic disorders. To determine how interaction between innate immune system and metabolic responses affected...