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- 29Chemistry
- 23Organic compounds. Synthesis.
- 22Catalysis
- 22Metabolomics
- 21Capillary electrophoresis.
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Spring 2023
In this thesis, rare-earth-containing chalcogenides and oxychalcogenides were sought with the aim to identify new crystal structures and to evaluate their potential as optical and thermoelectric materials. They were synthesized in the form of pure microcrystalline powders and single crystals...
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Spring 2023
Glycosylation is one of the most abundant and diverse post-translational modifications. Glycans participate in various key biological functions and processes including immunity, cell adhesion, endocytosis, exocytosis, molecular trafficking, and signal transduction. Previous work from our lab...
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Insights on local chemical structure of chalcogenide photovoltaic materials using solid state NMR spectroscopy
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Quaternary chalcogenides with the formula I2-II-IV-VI4 have emerged as promising candidates for photovoltaic materials, but many details about their structures remain poorly understood. This thesis describes the synthesis, structure determination, and optical properties of the sulfides Cu2MTtS4...
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Development of New Late-Stage Labeling Methods with Labeled Carbon for Stabilized Carboxylic Acids and α-Amino Acids
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Isotope labeling of small molecules is a crucial tool for drug discovery and understanding biochemical processes. Expanding the toolbox of a radiochemist with methods that allow late-stage labeling is therefore important. Of the methods that have been developed, the use of isotopically labeled...
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Development and Application of Electrospray Ionization Mass Spectrometry (ESI-MS) Methods for Measuring Carbohydrate-Active-Enzyme (CAZyme) Kinetics
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This thesis focuses on the development of electrospray ionization mass spectrometry (ESI-MS)-based methods for measuring carbohydrate-active enzyme (CAZyme) kinetics and their applications for profiling CAZyme specificity, glycoprotein remodeling and disease diagnosis. Chapter 2 introduces...
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Spring 2023
Trace elements are naturally occurring in the environment and important to human health. Elevated concentrations of trace elements present in food could cause adverse health outcomes. Among trace elements, arsenic adversely affects about 200 million people around the world, whose drinking water...
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Microscopic and Macroscopic Insights into Second Order Nonlinear Optics through Computational and Experimental Routes
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The challenge with obtaining physical insights into physiochemical phenomena is connecting the macroscopic observables with the microscopic processes in a system. In second-order nonlinear optical spectroscopy, experimental techniques such as vibrational sum frequency generation (vSFG) and second...
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Development of Small Molecules Towards Novel Protein Targets: From Selective Androgen Receptor Modulators to Affinity Probes for a Novel Immunological Target
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Cancer is a group of diseases that result from the uncontrollable growth of cells, which eventually can metastasize to other parts of the body, resulting in spread of the cancer. Chemotherapy, radiotherapy, surgery, and immunotherapy are the main pillars of cancer therapeutics. In recent years,...
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Spring 2023
Sialic acid is a monosaccharide found at the non-reducing end of cell surface glycans. Among the many important roles in mammals, sialic acid commonly serves as a ligand for glycan binding proteins, such as in host self-recognition (Siglecs), response to infection (Selectins), and in viral...
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Boron-Mediated Lignocellulose Degradation. Design, Synthesis, Properties, and Applications of Boron-Containing Naphthoids
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Lewis acidity is a molecule’s tendency to accept a pair of electrons. Trivalent boron compounds are archetypical Lewis acids due to the presence of a vacant p orbital, leading to many uses in organic synthesis. For example, boron trihalides use their intrinsic Lewis acidity to accept ether oxygen...