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Skip to Search Results- 11West, Frederick (Chemistry)
- 1Bennet, Andy (SFU Chemistry)
- 1Cambpell, Robert (Chemistry)
- 1Hall, Dennis (Chemistry)
- 1Lowary, Todd (Chemistry)
- 1Lucy, Charles (Chemistry)
- 1Ahmed Hamdy Mahmoud Elmenoufy
- 1Akuamoah Boateng, Maxwell
- 1Bonderoff, Sara A
- 1Bott, Tina Marie
- 1Dunbar, Christine R
- 1Fradette, Ryan J
- 2Interrupted Nazarov reaction
- 2Nazarov reaction
- 11,3-oxathiane
- 1Acetylcholine
- 1Allylic alcohol transposition
- 1Alternative Nazarov reaction
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Fall 2012
5-Membered carbocycles are ubiquitous in natural products and synthetic drugs. Methods of generating them are therefore valuable, and the ability to do so in a stereospecific and enantioselective manner while making considerable gains in molecular complexity with additional incorporation of...
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The construction of diverse nitrogen-containing heterocycles via the reaction of amines of azides with metallocarbenes
DownloadFall 2011
A fundamental goal in organic chemistry is the development of new and innovative ways of transforming simple building blocks into complex structures. The formation of ylides from the reaction of metallocarbenes with heteroatoms, such as the nitrogen of an amine or azide, is an example of a...
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The [1,2]-Stevens Rearrangement of Oxonium Ylides: Synthetic Applications and Mechanistic Studies
DownloadSpring 2016
The Stevens [1,2]-rearrangement of onium ylides has been employed as a valuable synthetic method to construct new C-C bonds. Oxonium ylides are reactive intermediates that undergo facile Stevens rearrangement under mild conditions. In the last several decades, the Stevens rearrangement of oxonium...
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Synthetic Studies Towards (+)-Dactylol Utilizing an Oxonium Ylide Rearrangement and Related Studies.
DownloadFall 2011
Dactylol is a structurally interesting sesquiterpene natural product. One of its key structural features is an the eight-membered ring. The challenges of synthesizing an eight membered ring are discussed in Chapter 1. In addition, various methods for generating an eight-membered ring are...
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Synthesis of Medium-Sized Oxygen and Nitrogen Heterocycles via Stevens Rearrangement of Sulfonium Ylides and Formal Synthesis of (+)-Laurencin
DownloadFall 2017
Medium-sized cyclic ether and amine motifs often constitute the framework of a variety of natural products with interesting biological activities. As a result, the construction of these heterocycles is an important subject in organic synthesis, which has triggered the development of many...
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Synthesis of Lipopolysaccharide O-antigens from Klebsiella pneumoniae Serotype O2a as Molecular Probes for Biosynthetic Studies
DownloadFall 2018
Many Gram-negative bacteria are pathogenic organisms that can cause disease and death. As antibiotic resistance and nosocomial disease occurrences both increase, these infections are becoming more problematic. These issues can be partially attributed to lipopolysaccharide (LPS), which is a major...
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Spring 2015
Five-membered carbocycles are highly prevalent motifs in natural products and pharmaceutical drugs. Finding routes towards these moieties has been an attractive area of pursuit in synthetic organic chemistry. The Nazarov reaction is one that has been widely used to access cyclopentenone...
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Fall 2014
This dissertation expands the scope and understanding of the Nazarov electrocyclization and interception of the reactive cyclopentenyl cation intermediate that is formed though a 4π electrocyclization of a pentadienyl cation. An intermolecular process for interrupting the Nazarov is discussed....
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Spring 2015
Diastereomeric piperidinium salts were prepared as substrates for the Stevens [1,2]-rearrangement of ammonium ylides, the key step in a proposed synthetic route towards lysergic acid, a valuable compound in medicinal and synthetic chemistry. Because of unexpected reactivity seen in the alkylation...
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Developing an M3 Antagonist for Molecular Imaging of Muscarinic Acetylcholine Receptors in Breast Cancer
DownloadFall 2021
The lack of the three targeted receptors, estrogen, progesterone, and the human epidermal growth factor receptor 2, causes difficulty in treating triple negative type cancers. Most often, patients with this type of malignancy have a low chance of survival. The focus of this work will be on...