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Skip to Search Results- 346Department of Medicine
- 214Department of Medical Sciences
- 121Department of Biomedical Engineering
- 72Department of Public Health Sciences
- 16Department of Medical Genetics
- 12Department of Laboratory Medicine and Pathology
- 2Coulombe, Marilyne G.
- 2Kinnaird, Adam
- 2Logus, J. Wayne (John Wayne), 1951-
- 2Srivastava, Nutan
- 2Verma, Anila.
- 1Abbasi Dezfouli, Meysam
- 14MRI
- 11Gene expression.
- 8DNA repair.
- 8Primary Biliary Cholangitis
- 7Copper. Physiological transport.
- 7Fibroblasts.
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Fall 2022
Background Muscular dystrophy (MD) is a group of inherited neuromuscular disorders with heart disease as a leading cause of morbidity and mortality. Dystrophinopathies such as Duchenne and Becker MD, limb-girdle MD, type 1 myotonic dystrophy (DM1), and facioscapulohumeral MD are most associated...
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Understanding Heart Failure in Patients with Dilated Cardiomyopathy: A Direct Tissue Analysis from Explanted Human Hearts
DownloadFall 2022
Background Chronic heart failure (HF) remains a rising global epidemic that affects both adults and children population. The causes of HF are heterogeneous, and syndromes are often complicated by concomitant disorders such as iron deficiency (ID) and diabetes. Comorbidities not only complicate...
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Understanding the Context of Pharmacy Practice Change: Gaining insight into the professional culture of pharmacy and pharmacists’ personality
DownloadFall 2014
Background: Pharmacists around the world are being asked to adopt, and integrate, an increasing number of clinical services into their practices. Evidence for the efficacy of pharmacists’ interventions in patient care also continues to grow. Traditional approaches to understanding practice change...
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Unveiling the pathway for the nuclear translocation of the large mitochondrial enzyme Pyruvate Dehydrogenase Complex (PDC)
DownloadSpring 2021
Pyruvate dehydrogenase complex (PDC) is a mitochondrial enzyme that links glycolysis to oxidative phosphorylation by decarboxylating glucose-derived pyruvate to produce acetyl-CoA that is used in the Krebs cycle. PDC was initially thought to reside only in the mitochondrial matrix but we recently...
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Use of Guideline-directed Medical Therapy in Patients ≥65 years after the Diagnosis of Heart Failure: A Canadian Population-based Study
DownloadFall 2023
Background: Guideline-directed medical therapy (GDMT) improves clinical outcomes in patients with heart failure (HF) with reduced ejection fraction (HFrEF). Despite proven efficacy, GDMT are under-utilized in clinical practice. The current study examines GDMT utilization after incident...