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Skip to Search Results- 2Veldhoen, Richard
- 1ALSHUMAIMERI, NADA A.
- 1Acevedo Morantes, Claudia Y
- 1Aderibigbe, Ayodeji O.
- 1Ahsan, Irfan.
- 1Alabi, Adekunle
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Study of calcineurin interaction with inhibitor-1 and natural products. Towards novel calcineurin inhibitors
DownloadSpring 2012
Calcineurin (CaN) is an eukaryotic Ser/Thr protein phosphatase that plays an important role in lymphocyte activation. Inhibition of CaN leads to immune system suppression, a necessary procedure in organ transplantation. However, use of CaN inhibitors results in toxic side effects. The search for...
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Sustained acidosis and phenylephrine activate the myocardial Na+/H+ exchanger through phosphorylation of Ser770 and Ser771
DownloadSpring 2010
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitously expressed membrane protein that regulates myocardial intracellular pH. Inhibition of NHE1 prevents hypertrophy and reduces ischemia-reperfusion (I/R) injury in animal models. To understand the regulation of NHE1 in the myocardium...
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Tau seeding in a HEK cell model is influenced by aggregation inducers and cellular chaperones
DownloadFall 2022
The tau protein is a microtubule associated protein whose misfolding and subsequent aggregation have been associated with a group of neurodegenerative diseases known as tauopathies. Studying tau in a lab setting has been crucial for the advancement of knowledge and technology used to treat people...
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Fall 2019
Breast cancer is the leading cause of death among women worldwide. Fortunately, death rates have been declining since 1990, due to the increase in early detection, testing, and improved treatment. However, despite the advancement of targeted and hormone therapies for certain molecular sub-types...