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Skip to Search Results- 2Lohmeier, Elke Monika, 1955-
- 2Veldhoen, Richard
- 1ALSHUMAIMERI, NADA A.
- 1Acevedo Morantes, Claudia Y
- 1Aderibigbe, Ayodeji O.
- 1Ahsan, Irfan.
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Spring 2010
More than 90% of human genes undergo a processing step called splicing, whereby non-coding introns are removed from initial transcripts and coding exons are ligated together to yield mature messenger RNA. Roughly 50% of human genetic diseases correspond to aberrant splicing. Splicing is...
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Structural and Functional Analysis of Intracellular Loop 5 of the NHE1 Isoform of the Na+/H+ Exchanger
DownloadFall 2017
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is an integral membrane protein that regulates intracellular pH. It removes a single intracellular proton in exchange for one extracellular sodium ion. It has a large 500 amino acid N-terminal membrane domain that mediates transport and consists...
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Spring 2011
Powerful mechanisms of genetic interference in both unicellular and multicellular organisms are based on the sequence-directed targeting of DNA or RNA by small effector RNAs. In many bacteria and almost all archaea, RNAs derived from clustered, regularly interspaced, short palindromic repeat...
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Fall 2015
Over 90% of eukaryotic genes are initially expressed as precursor-messenger RNAs (pre-mRNAs) that contain coding exon sequences interrupted by non-coding intron sequences. The introns are excised and exons are ligated together to form messenger RNA (mRNA) through a process called splicing....
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Fall 2014
Rhomboids are a family of intramembrane serine peptidases that cleaves a peptide bond of a substrate protein in the lipid bilayer. Various cellular processes such as cell differentiation and apoptosis have been linked to rhomboids proteolytic activty. More precisely, active and inactive rhomboids...
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Spring 2019
Exons, protein coding regions in eukaryotic genes, are interrupted by non-coding introns that must be removed from transcribed pre-mRNA prior to translation into protein. Introns are removed, and exons ligated, in a process called pre-mRNA splicing. Conserved sites within the intron, the 5′ and...