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Skip to Search Results- 2Veldhoen, Richard
- 1Acevedo Morantes, Claudia Y
- 1Aderibigbe, Ayodeji O.
- 1Ahsan, Irfan.
- 1Andrin, Christi.
- 1Arnason, Terra Gayle.
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Fall 2020
Cellular responses to stress are an integral part of cardiovascular physiology and pathology, and endoplasmic reticulum (ER) stress is the key component in the development and progression of various heart diseases. However, the relative contribution of ER stress pathways to muscle damage and...
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Mechanisms of Prion Disease: Initial Misfolding of the Prion Protein and Metabolomic Changes in the Brain
DownloadFall 2020
Prion diseases are neurodegenerative diseases that are caused by the misfolding and aggregation of cellular prion protein (PrPC) into the pathogenic form termed PrPSc. To contribute to a better understanding of the mechanism of prion disease, in this thesis I present my work on the structural...
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Spring 2020
Human cytomegalovirus (HCMV) infects 40–70% of the adult population in developed countries, and this rate increases with age. HCMV infection is normally latent with no noticeable symptoms in individuals with a healthy immune system. However, the infection can cause problems in immune-compromised...
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Fall 2020
Neurodegenerative diseases are a rising concern worldwide. Currently 10% of people aged 65 or more are diagnosed with a neurodegenerative disease and this number is predicted to triplicate by 2050. In developed societies approximately one percent of the global gross domestic product is allocated...
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Fall 2019
Breast cancer is the leading cause of death among women worldwide. Fortunately, death rates have been declining since 1990, due to the increase in early detection, testing, and improved treatment. However, despite the advancement of targeted and hormone therapies for certain molecular sub-types...
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Insights into the Role of Phosphatidylethanolamine N-methyltransferase and the PC:PE Ratio in Liver Function
DownloadSpring 2019
PEMT is quantitatively important in the liver and is responsible for approximately 30% of hepatic PC synthesis, with the remaining 70% synthesized by the CDP-choline pathway. HFD-fed Pemt-/- mice and LPcyt1a-/- mice both develop NAFLD associated with reduced VLDL secretion and a reduced hepatic...
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Spring 2019
Exons, protein coding regions in eukaryotic genes, are interrupted by non-coding introns that must be removed from transcribed pre-mRNA prior to translation into protein. Introns are removed, and exons ligated, in a process called pre-mRNA splicing. Conserved sites within the intron, the 5′ and...
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Fall 2019
Human prion diseases present as sporadic, familial, infectious, or iatrogenic forms. They include diseases such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), and Fatal Familial Insomnia (FFI). The wide range of phenotypic variation in human prion diseases is...
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SLC4A11 in Blinding Endothelial Corneal Dystrophies: Characterization, Molecular Defect and Potential Therapeutic Strategy
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Endothelial Corneal Dystrophies (ECD), genetic blinding diseases with a heterogeneous pathophysiology, are the leading cause of endothelial keratopathy (corneal transplants). Patients manifest symptoms, including corneal edema with increased corneal thickness and loss of corneal endothelial cells...
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Quantitative Label-Free Comparative Proteomic Analyses of Eukaryotic Tissues via Mass Spectrometry
DownloadFall 2018
In recent years, rapid advances in genomic and transcriptomic sequencing technologies have enabled the compilation of vast libraries of protein sequences and thus an explosion in bioinformatics-based fields of research. Among these is proteomics – the study of global protein abundance within a...