This decommissioned ERA site remains active temporarily to support our final migration steps to https://ualberta.scholaris.ca, ERA's new home. All new collections and items, including Spring 2025 theses, are at that site. For assistance, please contact erahelp@ualberta.ca.
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Skip to Search Results- 2Veldhoen, Richard
- 1ALSHUMAIMERI, NADA A.
- 1Abou Farraj, Rabih
- 1Acevedo Morantes, Claudia Y
- 1Aderibigbe, Ayodeji O.
- 1Ahsan, Irfan.
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Fall 2024
DNA serves as a detailed blueprint for cellular functions, but continuous exposure to damaging agents poses a threat to genomic stability, especially through DNA double-strand breaks. Cells utilize two main repair pathways, non-homologous end joining (NHEJ) and homologous recombination (HR), to...
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Investigation of CD36-Induced Anti-Angiogenic Signalling Platform via Proximity Biotinylation
DownloadFall 2024
In response to hypoxic conditions, tumours secrete pro-angiogenic factors that stimulate the development of new blood vessels. Given the critical role of angiogenesis in tumour progression, therapies counteracting cancer neovascularization have been developed. However, clinical studies have shown...
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Fall 2024
Viral diseases are a constant threat that have profound impact on global health, economics and societies. Understanding virus-host interactions is key for advancing our knowledge of viral replication and pathogenesis, and thus for the development of effective antiviral strategies to better...
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Spring 2024
Matrix metalloproteinase 2 (MMP2), also known as gelatinase A or 72 kDa type IV collagenase, is a member of a family of 25 different Zn2+-dependent endopeptidases that cleave a broad range of proteins including extracellular matrix proteins (such as collagens, laminin, fibrillin and aggrecan),...
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Novel Isotope Labeling Strategies for NMR-Based Structure Determination of High Molecular Weight Proteins
DownloadSpring 2023
Solution NMR studies of high molecular weight proteins suffer from inadequate side-chain information and rapid signal decay. Selective 1H, 13CH3-methyl labelling of perdeuterated proteins has been the standard approach addressing these limitations but suffers from a lack of information about the...
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Fall 2023
Prion diseases are a group of deadly neurological disorders caused by the abnormal folding of the prion protein into an infectious form known as PrPSc. Chronic wasting disease is a prion disease affecting cervids such as deer, elk, moose, and reindeer. Despite ongoing efforts to understand prion...
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Role of MMF1 Gene in Mannosylerythritol Lipid Secretion and Sustainable Biosurfactant Production from Brackish Water
DownloadFall 2023
This thesis investigates the secretion of mannosylerythritol lipid (MEL) in the JCM10317 strain of P. antarctica, and the potential for a more cost-effective, environmentally friendly production process for MEL. The study demonstrates that the Pa MMF1 gene is necessary for the secretion of...
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Fall 2023
When calcium enters the cytosol of a muscle cell from the SR, it initiates muscle contraction, while its removal by the sarco(endo)plasmic reticulum calcium ATPase (SERCA) induces muscle relaxation. SERCA's activity is regulated by Phospholamban (PLN), which can reversibly inhibit its apparent...
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Fall 2023
Lipids are integral components of all cells. Lipid molecules form the membrane and control membrane integrity while storage lipids act as a source of energy for the cell. The chemical properties of lipids are determined by the composition of the molecule’s acyl chain moieties. Incorporation of...
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Measuring proteomic changes associated with viral infections and neurodegenerative diseases using mass spectrometry
DownloadFall 2023
Viral infection and the resultant cellular stress can trigger significant changes to the cellular host proteome. Viral proteases essential to viral replication have been shown to cleave human host protein substrates as a mechanism of immune response evasion. The severe acute respiratory syndrome...