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Skip to Search Results- 1Armanious, Gareth
- 1Bak, Jessi J.
- 1Ceholski, Delaine K
- 1Gorski, Przemyslaw A
- 1Kemp, Grant A.
- 1Primeau, Joseph
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Fall 2023
When calcium enters the cytosol of a muscle cell from the SR, it initiates muscle contraction, while its removal by the sarco(endo)plasmic reticulum calcium ATPase (SERCA) induces muscle relaxation. SERCA's activity is regulated by Phospholamban (PLN), which can reversibly inhibit its apparent...
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Spring 2020
Oscillating cytosolic calcium concentrations dictate the contraction-relaxation cycles of muscle cells. Calcium release from the sarcoplasmic reticulum (SR) to the cytosol stimulates muscle contraction, while active transport of calcium back into the SR triggers muscle relaxation. Calcium...
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Spring 2020
Calcium homeostasis is essential and central to a variety of cellular processes from cell life and death pathways to metabolism to muscle contraction. One component that is essential to intracellular calcium regulation is known as the sarco(endo)plasmic reticulum Ca-ATPase, or SERCA. SERCA...
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Fall 2013
Sodium proton exchangers (NHEs) are polytopic membrane proteins that, in archaea, bacteria, yeast and plants, provide increased salt tolerance by removing excess toxic sodium, and in mammals regulate cell volume, growth, differentiation, proliferation, migration and apoptosis in relation to...
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Fall 2013
In human cells, oscillations in calcium concentration serve as a mechanism for controlling a variety of physiological processes including muscle contraction and relaxation. The sarcoplasmic reticulum (SR) is a calcium storage organelle in muscle cells that contains a calcium pump (SERCA) required...
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Fall 2012
The movement of calcium across sarcoplasmic reticulum (SR) membranes is essential in the contraction-relaxation cycle of muscle. An influx of calcium into the muscle cell from the SR triggers muscle contraction and its removal by the sarco(endo)plasmic reticulum calcium ATPase (SERCA) causes...
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Biochemical and structural characterization of CpxP and CpxA, key components of an envelope stress response in Escherichia coli
DownloadFall 2012
The Cpx two‐component signal transduction pathway of Escherichia coli consists of an inner membrane‐localized sensor histidine kinase, CpxA, the response regulator, CpxR, and the novel periplasmic accessory protein, CpxP. These proteins mediate a bacterial stress response, sensing envelope...