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Skip to Search Results- 1Aderibigbe, Ayodeji O.
- 1Armanious, Gareth
- 1Augustine, Aruna M
- 1Bak, Jessi J.
- 1Ceholski, Delaine K
- 1Coccaro, Ersilia
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An NMR-based approach to the structural and functional investigation of the Na+/H+ exchanger NHE1
DownloadFall 2013
The Na+/H+ exchanger isoform 1 (NHE1) is the predominant isoform in mammalian cells, and regulates intracellular pH and ion concentrations. NHE1 also interacts with numerous proteins and signalling pathways. Consequently, it has been found to influence cell volume, growth, differentiation, and...
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Biochemical and structural characterization of CpxP and CpxA, key components of an envelope stress response in Escherichia coli
DownloadFall 2012
The Cpx two‐component signal transduction pathway of Escherichia coli consists of an inner membrane‐localized sensor histidine kinase, CpxA, the response regulator, CpxR, and the novel periplasmic accessory protein, CpxP. These proteins mediate a bacterial stress response, sensing envelope...
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Spring 2020
Calcium homeostasis is essential and central to a variety of cellular processes from cell life and death pathways to metabolism to muscle contraction. One component that is essential to intracellular calcium regulation is known as the sarco(endo)plasmic reticulum Ca-ATPase, or SERCA. SERCA...
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Spring 2011
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitous membrane protein that exchanges one intracellular H+ for an extracellular Na+, thereby regulating cell pH and volume. NHE1 catalytic activity is mediated by a transmembrane (TM) domain with 12 transmembrane segments. We performed...
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Fall 2023
When calcium enters the cytosol of a muscle cell from the SR, it initiates muscle contraction, while its removal by the sarco(endo)plasmic reticulum calcium ATPase (SERCA) induces muscle relaxation. SERCA's activity is regulated by Phospholamban (PLN), which can reversibly inhibit its apparent...
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Fall 2013
In human cells, oscillations in calcium concentration serve as a mechanism for controlling a variety of physiological processes including muscle contraction and relaxation. The sarcoplasmic reticulum (SR) is a calcium storage organelle in muscle cells that contains a calcium pump (SERCA) required...
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Fall 2012
The movement of calcium across sarcoplasmic reticulum (SR) membranes is essential in the contraction-relaxation cycle of muscle. An influx of calcium into the muscle cell from the SR triggers muscle contraction and its removal by the sarco(endo)plasmic reticulum calcium ATPase (SERCA) causes...
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Spring 2020
Oscillating cytosolic calcium concentrations dictate the contraction-relaxation cycles of muscle cells. Calcium release from the sarcoplasmic reticulum (SR) to the cytosol stimulates muscle contraction, while active transport of calcium back into the SR triggers muscle relaxation. Calcium...
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Fall 2017
Mammalian Na+/H+ Exchanger 1 is a ubiquitously expressed membrane protein, which is dedicated to maintaining the acid-base balance in the cell. This balance is brought about by the exchange of one intracellular proton in exchange for extracellular sodium ion. NHE1 is the predominant isoform found...
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Structural and Functional Analysis of Intracellular Loop 5 of the NHE1 Isoform of the Na+/H+ Exchanger
DownloadFall 2017
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is an integral membrane protein that regulates intracellular pH. It removes a single intracellular proton in exchange for one extracellular sodium ion. It has a large 500 amino acid N-terminal membrane domain that mediates transport and consists...