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Skip to Search Results- 3Riddell, Michael C.
- 3Yardley, Jane E.
- 2Kenny, Glen P.
- 2Perkins, Bruce A.
- 2Sigal, Ronald J.
- 1Beaulieu-Bayne, Emilie
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Fall 2019
Background: Diabetes is characterized by dysregulated glucose homeostasis that leads to hyperglycemia, due in part to increased hepatic glucose production (GP) and insulin resistance. Excessive levels and/or action of glucocorticoids (GCs) are associated with obesity, insulin resistance, and...
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Improving Islet Function and Engraftment by Co-culturing Islets with Mesenchymal Stem Cells and the Formation of Pseudoislets
DownloadFall 2018
Islet transplantation has proven to be efficacious in preventing severe hypoglycemia and restoring insulin independence in selected patients with type 1 diabetes. The well-established procedure has gained popularity due to notable refinements over the past two decades. However, islet...
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Spring 2024
The conservation of ketone body metabolism across various domains of life, including eukaryotes, bacteria, and archaea, underscores its pivotal role in physiological processes. Primarily activated during carbohydrate scarcity, ketone body metabolism provides alternative energy, mainly to the...
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Living with a Machine: A Critical Focused Ethnography of Diabetes Practices in the Context of Insulin Pumps
DownloadFall 2021
Background: Insulin pump utilization has increased significantly over the past 30 years and despite extensive research on adapting to, living with, and managing diabetes, there is a paucity of research on the enactment of diabetes in the context of insulin pumps. Purpose: I aimed to explore...
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Long-term effects of early-life gut microbiota perturbations on pancreatic islet development
DownloadFall 2021
Impaired secretion of insulin from pancreatic beta-cells, along with loss of cell mass, is one of the hallmarks of the pathogenesis of type 2 diabetes, a metabolic disorder characterized by chronic hyperglycemia. In humans, beta-cells’ ability to secrete insulin in response to glucose is acquired...
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Performing resistance exercise before versus after aerobic exercise influences growth hormone secretion in type 1 diabetes
Download2014-02-01
Yardley, Jane E., Sigal, Ronald J., Riddell, Michael C., Perkins, Bruce A., Kenny, Glen P.
We compared growth hormone (GH) and plasma glucose (PG) levels in type 1 diabetic individuals performing aerobic before resistance exercise (AR) to when resistance exercise was performed first (RA). In AR, GH secretion declined in late exercise while it rose throughout exercise in RA, resulting...
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2013-12-01
Yardley, Jane E., Sigal, Ronald J., Perkins, Bruce A., Riddell, Michael C., Kenny, Glen P.
It is relatively well known that moderate-intensity aerobic exercise increases the risk of hypoglycemia in individuals with type 1 diabetes. Conversely, brief high-intensity (anaerobic) activity can cause post-exercise hyperglycemia. Recent evidence has indicated that including small amounts of...
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The “Ups” and “Downs” of a Bike Race in People with Type 1 Diabetes: Dramatic Differences in Strategies and Blood Glucose Responses in the Paris-to-Ancaster Spring Classic
Download2015-01-01
Yardley, Jane E., Zaharieva, Dessi P., Jarvis, Chris., Riddell, Michael C.
Objective: Recommendations for insulin adjustments and carbohydrate intake exist for individuals with type 1 diabetes undertaking moderate exercise. Very few guidelines exist for athletes with type 1 diabetes competing in higher intensity and/or longer duration events. This observational study...