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Skip to Search Results- 1Bedard, Janice
- 1Cleary, Stuart
- 1Miranda Tapia, Ana
- 1Pisanski, Annette
- 1Reklow, Robert J.
- 1Robertson, Kirsten
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Spring 2022
Breathing is a vital behavior regulated by the brainstem neurons. To maintain regular ventilation, these neurons need to establish proper interactions with other neurons and process signals transmitted by various neurotransmitters. Located in the ventrolateral medulla, the neurons in the...
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Elucidating the origin of expiratory abdominal activity during sleep and analysis of its manifestation in conditions of an impaired inspiratory drive
DownloadSpring 2024
This dissertation explored respiratory control mechanisms during sleep, with a specific focus on the contribution of the lateral parafacial area (pFL) to the generation of abdominal recruitment. Existing theories posit the preBötzinger complex (preBötC) as the inspiratory oscillator and identify...
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Mechanisms underlying P2Y1 receptor-mediated excitation of the inspiratory network in vitro; and NPY-induced stress resilience in vitro and in vivo
DownloadSpring 2021
The present thesis will discuss the cellular and molecular mechanisms by which neurochemical systems modulate the activity of CNS networks underlying breathing and anxiety. The thesis is divided into two parts. The first part examines the mechanisms by which the neuromodulator/neurotransmitter...
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Postnatal development of the purinergic signaling system in the preBötzinger Complex; implications for the hypoxic ventilatory response
DownloadFall 2023
Low oxygen (hypoxia) evokes the biphasic hypoxic ventilatory response (HVR), in which carotid-body chemoreceptors trigger a rapid increase in ventilation (VE) followed by a centrally-mediated, secondary hypoxic depression of respiration (HRD) and metabolic rate (VO2) that involves adenosine. In...
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The effects of a volitional breathing technique on swallowing and respiratory coordination in individuals with amyotrophic lateral sclerosis (ALS)
Download2016-05-04
Bedard, Janice, Williston, Heidi, Cleary, Stuart, Robertson, Kirsten
Introduction: Breathing and swallowing are integrally related biomechanical processes that are often impaired in people with ALS (PALS). This may lead to significant functional impairments that negatively impact their quality of life. Purpose: The purpose of the overall project was to investigate...